扶正利胆方对贲门癌术后胆囊结石发生的影响  

Investigation of Fuzheng- lidan herbs on cholelithiasis after cardiac cancer resection

作　　者：阎晓路[1] 高哲[2] 邓新娜[1] 

机构地区：[1]河北省人民医院肿瘤科,河北石家庄050051 [2]河北省人民医院内分泌科,河北石家庄050051

出　　处：《河北中医》2015年第8期1141-1144,共4页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察扶正利胆方对贲门癌术后胆囊结石发生的影响探讨其作用机制。方法将120例贲门癌术后患者随机分为2组。治疗组60例术后第10 d开始口服扶正利胆方,连服3个月;对照组60例行常规抗炎、补液等治疗。2组均于术前3 d,术后1、3、6个月测空腹血清胆囊收缩素(CCK)浓度,并做胆囊超声测定空腹及脂肪餐后30 min、l h后胆囊最大纵切面积、长径、短径,计算胆囊超声容积、胆囊收缩率等,并记录胆囊结石发生人数,比较2组手术后胆囊的容积、胆囊收缩率、空腹血清CCK浓度及术后胆囊结石发病率。结果治疗组术后较对照组胆囊容积减小,胆囊收缩率增高,差异均有统计学意义(P<0.05)。治疗组术后较对照组空腹血清CCK浓度明显升高,差异有统计学意义(P<0.05)。术后6个月治疗组胆囊结石发生病率较对照组低,差异有统计学意义(P<0.05)。结论扶正利胆方可以提高贲门癌术后患者血清CCK浓度,改善胆囊收缩功能,降低胆囊结石发病率。Objective To investigate the effects and mechanism of Fuzheng-lidan herbs on cholelithiasis after cardiac cancer resection.Methods 120 patients after cardiac cancer resection were randomly divided into two groups.60 patients in treatment group received Fuzheng-lidan herbs 10 d after operation, continuous oral administra-tion for 3 months.60 patients in control group received routine therapy, including anti-inflammation and fluid infu-sion.The concentration of fasting serum cholecystokinin （ CCK） was detected 3 d before operation and 1, 3, 6 months after operation in two groups.The maximum longitudinal section area, long diameter and short diameter of gallbladder were measured by cholecystosonography at empty stomach and 30 min, 1 h after fat meals, as well as gallbladder vol-ume, gallbladder shrinkage rate, etc.The number of people with cholelithiasis was recorded.The gallbladder volume, gallbladder shrinkage rate, fasting serum CCK concentration and cholelithiasis morbidity after operation were com-pared between two groups.Results After operation, the gallbladder volume was decreased and gallbladder shrinkage rate was increased in treatment group as compared with those in control group.The differences were statistically signif-icant （P〈0.05）.The concentration of fasting serum CCK after treatment was obviously increased in treatment group as compared with that in control group （P〈0.05）.The morbidity of cholelithiasis 6 months after operation in treat-ment group was lower than that in control group （P〈0.05）.Conclusion Fuzheng-lidan herbs can enhance fast-ing serum CCK concentration of patients after cardiac cancer resection, improve gallbladder contractability, and de-crease cholelithiasis morbidity.

关 键 词：胆结石 胃切除术 副作用 胃肿瘤 外科学 贲门 

分 类 号：R322.4[医药卫生—人体解剖和组织胚胎学] R666.61[医药卫生—基础医学]