高迁移率族蛋白B1对Th17/Treg平衡的调节  

HMGB1: Regulator of Th17 / Treg Balance

作　　者：周天(综述)[1] 丁家望[1] 郑霞霞(审校)[1] 

机构地区：[1]三峡大学第一临床医学院,宜昌市中心人民医院心内科,湖北宜昌443003

出　　处：《医学综述》2015年第14期2519-2521,共3页Medical Recapitulate

摘　　要：辅助性T细胞17(Th17)细胞在自身免疫性疾病、移植排斥反应和感染性疾病中发挥促炎作用,而调节性T细胞(Treg细胞)则抑制炎症反应。Th17/Treg平衡在维持机体免疫稳态中发挥重要作用。高迁移率族蛋白B1(HMGB1)作为一种晚期炎性介质可作用于Th17、Treg细胞上的Toll样受体或糖基化终产物受体,从而直接调节其分化及功能。HMGB1还可通过调节其他免疫细胞(树突状细胞、单核细胞等)炎性因子的分泌来影响Th17细胞和Treg细胞分化、转化,从而调节Th17/Treg平衡。Th17 cells play a pro-inflammatory role in autoimmune diseases, allograft rejection and inflammatory diseases,while Treg cells function to restrain excessive effector T-cells immune responses.The Th17/Treg balance is crucial for the maintenance of immune homeostasis.As a late inflammatory mediator, high mobility group box 1（HMGB1） can directly regulate the development,differentiation and function activ-ity of Th17 and Treg cells through acting on Toll-like receptors and the receptor for advanced glycation end-products expressed on the two cells.In addition,HMGB1 can indirectly influence the differentiation and con-version of Th17 as well as Treg cells through regulating the function and cytokine secretion of other immune cells,such as dendritic cells and monocytes.

关 键 词：高迁移率族蛋白B1 辅助性T细胞17 调节性T细胞 

分 类 号：R392.11[医药卫生—免疫学]