维生素D及其受体基因多态性与疾病的关系研究进展  

Research Progress of Vitamin D Receptor Gene Polymorphism and Susceptibility to the Diseases

作　　者：邱戌旦[1,2] 朱益民[2] 

机构地区：[1]浙江省医学科学院,杭州310013 [2]浙江大学医学院,杭州310058

出　　处：《医学综述》2015年第14期2528-2530,共3页Medical Recapitulate

基　　金：浙江省科技计划项目(2013F50018)

摘　　要：维生素D受体(VDR)基因在人体组织中广泛表达,它的4个单核苷酸多态性位点FokⅠ、BsmⅠ、ApaⅠ和TaqⅠ与多种疾病发生均有关联。该文就近年来国内外所开展的VDR基因多态性与支气管哮喘、结核病、1型糖尿病、自身免疫性疾病和肿瘤的相关性进行综述,发现VDR基因多态性存在较大的种族差异,并可能受饮食、生活习惯、环境因素等的影响。VDR基因多态性的研究为进一步明确疾病的发病机制提供了理论基础。Vitamin D receptor （ VDR ） gene is widely expressed in human tissues, it has four single nucleotide polymorphisms loci FokⅠ,BsmⅠ,ApaⅠ and TaqⅠ which are associated with many diseases. Here is to make a review of the association between VDR polymorphisms with bronchial asthma,tuberculosis, type 1 diabetes,autoimmune diseases and cancer.It is discovered that,VDR gene polymorphisms have racial differences,and may be affected by diet,lifestyle and other environmental factors.The research on the genetic polymorphisms of VDR has provided theoretical basis to further clarify the pathogenesis .

关 键 词：维生素D受体 遗传 多态性 

分 类 号：Q346.5[生物学—遗传学]