吸烟对阿司匹林、氯吡格雷药效的影响  

The Impacts of Smoking on Pharmacodynamic Effects of Aspirin and Clopidogrel

作　　者：谢文剑[1] 陈绍良[1] 

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)心内科,南京210006

出　　处：《医学综述》2015年第14期2604-2606,共3页Medical Recapitulate

基　　金：江苏省临床医学科技专项(BL2013001)

摘　　要：抗血小板药物阿司匹林和氯吡格雷可抑制血小板黏附和聚集;防止血栓形成;延缓动脉阻塞性疾病的病情发展,是预防和治疗冠心病的常用药物。Framingham心脏研究结果显示,每日吸烟10支,能使男性心血管病死率增加18%,女性心血管病死率增加31%。但是,最近几个随机对照试验亚组分析表明,吸烟者比非吸烟者更能显著地从氯吡格雷中获益。该文回顾了相关的医学文献,就吸烟对阿司匹林、氯吡格雷药效的不同影响进行综述。Aspirin and clopidogrel can inhibit platelet adhesion and aggregation,prevent thrombosis and arterial occlusion progression.They are common antiplatelet drugs that prevent as well as treat cardiovascular disease（ CVD） .The Framingham Heart Study have showed that smoking 10 cigarettes per day made the male cardiovascular mortality increased 18%,31% increase in women.Subgroup analysis of randomized controlled trials,however,have recently found that significantly greater benefit from clopidogrel were seen in smokers than in nonsmokers.This study sought to review the medical literature to evaluate the different roles of smok-ing in pharmacodynamic response to aspirin and clopidogrel.

关 键 词：吸烟 阿司匹林 氯吡格雷 

分 类 号：R541[医药卫生—心血管疾病]