中西医结合药物治疗慢性溃疡性结肠炎疗效观察  

Integrated Traditional Chinese Medicine-West Medicine for the Therapy of Chronic Ulcerative Colitis Report

作　　者：张金涛[1] 王晓锋[1] 陈浩漩[1] 

机构地区：[1]北京市通州区中医医院肛肠外科,北京101100

出　　处：《医学综述》2015年第14期2683-2684,F0003,共3页Medical Recapitulate

摘　　要：目的探讨中西医结合药物治疗轻-中度远端成人型慢性溃疡性结肠炎的疗效。方法选取2008年2月至2010年2月北京市通州区中医医院收治的轻-中度远端成人型慢性溃疡性结肠炎患者85例,采用投掷硬币法随机分为中西医结合组(45例)和西医组(40例)。中西医结合组:急性期口服美沙拉嗪肠溶片,灌肠剂为甲硝唑(无糖)100 m L+氢化可的松100 mg,缓解期用自制中药灌肠方(生地榆30 g、仙鹤草30 g、白茅根30 g、白芨15 g、苦参15 g、黄芩10 g、枯矾10 g、冰片3 g)灌肠;西医组:急性期口服美沙拉嗪,灌肠剂为甲硝唑(无糖)100 m L+氢化可的松100 mg,缓解期联合美沙拉嗪口服、灌肠。所有病例均获得2年以上随访,记录并分析两组病例用药时程、有效率、不良反应发生率、医药费用。结果中西医结合组与西医组用药时程[(27.5±2.7)d比(28.4±3.3)d]、有效率(93.3%比90.0%)比较差异无统计学意义(P>0.05);中西医结合组不良反应发生率、医药费用均显著低于西医组[6.7%比25.0%,(543±11)元比(1120±8)元,P<0.05]。结论中西医结合治疗方案用于轻-中度远端成人型慢性溃疡性结肠炎经济、安全、有效。Objective To evaluate the effect of integrated traditional Chinese medicine-west medicine （TCM-WM） therapy for mild-moderate adult distal chronic ulcerative colitis（M-M ACUC）.Methods This clinical randomized controlled trial was performed in Tongzhou Hospital of Traditional Chinese Medicine from Feb.2008 to Feb.2010.The observation group—TCM/WM group：45 cases of M-M ACUC were included, which were treated with oral mesalazine slow release tablets and topical metronidazole（glycoprival） 100 mL＋hydrocortisone 100 mg during acute stage,and during paracmasia self-made TCM medicine （ longleaf garden burnet root 30 g,hairyvein agrimonia herb 30 g,lalang grass rhizome 30 g,common bletilla tuber 15 g,light-yellow sophora root 15 g,baikal skullcap root 10 g,dried alum 10 g and synthetic borneol 3 g） was offered as enema.The control group—WM group：40 cases during the same period were included,and were treated with oral mesalazine slow release tablets and topical metronidazole（glycoprival） 100 mL＋hydrocortisone 100 mg during acute stage,and oral mesalazine slow release tablets combined with topical mesalazine were utilized during the paracmasia stage.All the cases were followed up for two years.The medication duration,effective-ness rate,side effect rate and the medical expense were recorded and analyzed.Results There was no signifi-cant difference between the TCM/WM group and the WM group：regarding the medication duration [ （27.5 ± 2.7） d vs （28.4 ±3.2） d] and effectiveness rate （93.3% vs 90.0%） （P〉0.05）,while the individual medical expense was （543 ±11） RMB for TCM/WM group,（1120 ±8） RMB for WM group,there was sta-tistically significant difference （ P 〈0.05 ） .And the side effect rate was 6.7% for TCM/WM group and 25.0% for WM group,with significant difference（P 〈0.05）.Conclusion The TCM-WM therapyis eco-nomic,safe and effective in the treatment of M-M ACUC.

关 键 词：慢性溃疡性结肠炎 中西医结合 灌肠方 

分 类 号：R2-031[医药卫生—中西医结合] R516.1[医药卫生—中医学]