可溶性CD_(105)和新蝶呤在急性冠状动脉综合征中的临床意义  

Clinical Significance of Soluble CD_(105) and Neopterin in Acute Coronary Syndrome

作　　者：刘浩[1] 

机构地区：[1]随州市中心医院心血管内科,湖北随州441300

出　　处：《医学综述》2015年第14期2687-2688,F0003,共3页Medical Recapitulate

摘　　要：目的探讨可溶性CD105(s CD105)和新蝶呤在急性冠状动脉综合征(ACS)中的临床意义。方法选取2011年1月至2013年12月随州市中心医院心血管内科收治的ACS患者72例。根据病情的不同将72例ACS患者分为急性心肌梗死组(AMI组,46例)和不稳定型心绞痛组(UA组,26例);另选择同期52例健康人群为对照组。46例AMI患者心电图检查结果显示,18例患者存在ST段抬高(A组),28例患者未存在ST段抬高(B组)。统计受试者血清s CD105、新蝶呤水平。结果ACS组血清s CD105、新蝶呤水平均显著高于对照组[(16.82±3.82)μg/L比(5.91±1.21)μg/L、(153.52±9.27)μg/L比(82.67±4.78)μg/L,P<0.05];A组血清s CD105、新蝶呤水平均显著高于B组[(20±4)μg/L比(16±4)μg/L、(158±10)μg/L比(154±9)μg/L,P<0.05];ACS患者经皮冠状动脉介入术后血清s CD105、新蝶呤水平均较经皮冠状动脉介入术前显著降低[(17±4)μg/L比(9±3)μg/L、(154±9)μg/L比(71±7)μg/L,P<0.01],血清s CD105与ACS呈正相关(r=0.392,P=0.009);血清新蝶呤与ACS呈显著正相关(r=0.381,P=0.012);血清s CD105、新蝶呤与烟龄均呈正相关(P<0.05);血清s CD105与血清新蝶呤呈明显正相关(r=0.435,P=0.008)。结论 ACS患者外周血中s CD105、新蝶呤表达水平较高,血清s CD105、新蝶呤与ACS发病及病情进展密切相关。Objective To explore the clinical significance of the soluble CD 105 （ sCD105 ） and neopterin in acute coronary syndrome（ ACS）.Methods A total of 72 ACS patients from Suizhou Central Hospital between Jan.2011 and Dec.2011 were included as the research objects.According to the condition of dis-ease,72 ACS patients were divided into acute myocardial infarction （ AMI group,46 cases） ,unstable angina group（UA group,26 cases）; Another 52 healthy people during the same period were included （ control group） as the research objects.According to the results of 46 AMI patients electrocardiogram inspection,18 patients had ST-elevation（ group A） ,28 cases had no ST segment elevation（ group B） .The sCD105 ,neopterin level were recorded.Results Serum sCD105 ,neopterin levels in ACS group were significantly higher than those in the control group[（16.82 ±3.82） μg/L vs （5.91 ±1.21） μg/L,（153.52 ±9.27） vs （82.67 ± 4.78） μg/L,P〈0.05]; serum sCD105 ,neopterin levels of group A were significantly higher than those of group B [（20 ±4） μg/L vs （16 ±4） μg/L,（158 ±10） μg/L vs （154 ±9） μg/L,P 〈0.05]; serum sCD105,neopterin level in ACS patients after PCI were significantly reduced than before PCI[（17 ±4） μg/L vs （9 ±3） μg/L,（154 ±9） μg/L vs （71 ±7） μg/L]（P〈0.01）;serum sCD105 was positively related with ACS（r=0.392,P=0.392）.Neopterin was significantly positively related to ACS（r=0.381,P=0.012）;serum sCD105 ,neopterin were both positively correlated with smoking history length （ P 〈0.05 ）;neopterin and serum sCD105 were significantly positively correlated（r =0.435,P =0.008）.Conclusion sCD105, neopterin present high expression in peripheral blood of ACS patients;serum sCD105 , neopterin are closely related tothe onset and progression of ACS.

关 键 词：急性冠状动脉综合征 可溶性CD105 新蝶呤 相关性 价值 

分 类 号：R442.8[医药卫生—诊断学]