大叶钩藤总生物碱抗抑郁作用初步研究  

Preliminary Study on Antidepressant Effect of Total Alkaloids fromUncaria macrophylla

作　　者：李影雄[1] 马存[2] 刘林生[1] 招丽娟[1] 王定勇[2] 

机构地区：[1]佛山市中医院药剂科,广东佛山528000 [2]广东药学院药科学院,广东广州510006

出　　处：《亚太传统医药》2015年第15期15-17,共3页Asia-Pacific Traditional Medicine

基　　金：广东省中医药局科研课题(20132030)

摘　　要：目的:研究大叶钩藤总生物碱的抗抑郁活性。方法:采用小鼠悬尾实验、小鼠强迫游泳实验和利血平致抑郁小鼠自主活动实验,考察大叶钩藤总生物碱的抗抑郁活性。结果:大叶钩藤总生物碱低(50mg/kg)、中(100mg/kg)、高(200mg/kg)剂量组均能减少小鼠悬尾和强迫游泳不动时间,并能增加利血平致抑郁小鼠自主活动次数,与空白对照组、模型对照组比较差异均有统计学意义(P<0.05或P<0.01)。结论:大叶钩藤总生物碱具有明显的抗抑郁作用。Objective：To study the antidepressant effect of total alkaloids from Uncaria macrophylla Wall. in mice. Methods：To investigate the antidepressant activities of total alkaloids from U. macrophylla by the mice tail suspension test, the mice forced swimming test and the freely active test in depressant mice caused by reserpine. Results： The different dose groups （50mg/kg, 100mg/kg, 200mg/kg） of total alkaloids from U. macrophylla could reduce the immobility time of mice in the tail suspension test and the forced swimming test, and also increase the times of free activities in the freely active test, compared with that of the control group or model group （P^0.05 or P^0.01）. Conclusion：The total alkaloids from U. macrophylla possessed the significant anti- depressant effect.

关 键 词：大叶钩藤 总生物碱 抗抑郁 

分 类 号：R285.5[医药卫生—中药学]