鲍曼不动杆菌感染患者抗生素的使用与耐药性分析  

Use of antibiotics and drug-resistance analysis in patients with Acinetobacter baumannii infection

作　　者：李荣琴[1] 方琪[1] 陶炫霖 李佳星[1] 

机构地区：[1]重庆市綦江区人民医院感染管理科,401420

出　　处：《检验医学与临床》2015年第15期2167-2169,共3页Laboratory Medicine and Clinic

基　　金：重庆市卫生和计划生育委员会医学科研计划项目(2013-2-245);綦江区科技计划项目(2014.048)

摘　　要：目的了解重庆市綦江区人民医院鲍曼不动杆菌感染现况及感染患者抗生素使用规范情况,并对其进行耐药性分析。方法选取2011年7月至2013年6月綦江区人民医院重症医学科鲍曼不动杆菌感染患者为研究对象,收集其病例资料和药敏结果并按时间段进行比较。结果綦江区人民医院重症医学科鲍曼不动杆菌医院感染率为3.94%,抗生素不规范使用率为20.63%,且呈现逐渐降低的趋势;药敏结果显示,綦江区人民医院鲍曼不动杆菌对所有试验抗生素耐药率超过50%,尤其对头孢他啶(CAZ)、头孢噻肟(CTX)、复方磺胺甲噁唑(T/S)三种药物呈现随着时间的变化而耐药率逐渐升高的现象。结论严格执行环境消毒和加强抗生素规范使用监管对降低多重耐药鲍曼不动杆菌感染和预防医院感染暴发具有重要意义。Objective To understand the current status of Acinetobacter baumannii infection in our hospital and the standardized situation of antibiotic use in the infection patients ,then to analyze the its drug‐resistance .Meth‐ods The patients with Acinetobacter baumannii infection in ICU from July 2011 to June 2013 were selected as the subjects and their medical data and drug susceptibility results were collected for conducting the analysis and compari‐son according to the time periods .Results The nosocomial infection rate of Acinetobacter baumannii in ICU was 3 .94% ,the non‐standard rate of antibiotic use was 20 .63% ,furthermore which showed the gradually decreasing trend ;the drug susceptibility results showed that the resistance of Aacinetobacter baumannii to all tested antibiotics exceeded 50% in our hospital ,especially the resistance to ceftazidime（CAZ） ,cefotaxime（CTX） and trimethoprim/sulfamethoxazole（T /S） was gradually increased over time .Conclusion Strictly executing the environment disinfec‐tion and strengthening the standardized antibiotic use and supervision have an important significance for reducing multi‐drug resistant Acinetobacter baumannii infections and preventing nosocomial infection outbreak .

关 键 词：鲍曼不动杆菌 抗生素 药敏试验 耐药率 

分 类 号：R515[医药卫生—内科学]