胰岛素泵治疗糖尿病合并甲亢31例临床疗效观察  

Insulin pump in treatment of diabetes combined with hyperthyroidism: a clinical observation of 31 cases

作　　者：戎丽琳[1] 沈显跃 陆杨[1] 宗志国[1] 张然[1] 

机构地区：[1]安徽省六安市立医院内分泌科,237000

出　　处：《淮海医药》2015年第5期427-428,共2页Journal of Huaihai Medicine

摘　　要：目的探讨胰岛素泵治疗糖尿病合并甲亢的临床效果。方法 2013年1月以前,28例糖尿病合并甲亢患者是采用间断皮下注射胰岛素控制血糖（对照组）,其中男16例,女12例,年龄27-76岁,平均年龄（29.5±16.4）岁,病程为诊断到16年,平均（3.4±6.7）年。从2013年1月开始应用胰岛素泵持续皮下注射胰岛素治疗糖尿病合并甲亢（观察组）31例,其中,男21例,女10例,年龄24-81岁,平均年龄（28.3±15.6）岁,病程为诊断到14年,平均（4.6±5.2）年。比较两种方法治疗后空腹血糖和餐后2h血糖水平,胰岛素每日平均用量（U/d）,血糖值达标时间（h）,低血糖发生率（%）。结果治疗前2组空腹血糖和餐后2h血糖水平差异无显著性（P〉0.05）,治疗后,观察组空腹血糖和餐后2h血糖低于对照组（P〈0.05）,胰岛素每日平均用量、血糖值达标时间、低血糖发生率均少于对照组（P〈0.05）。结论应用胰岛素泵持续皮下注射的临床效果优于胰岛素间断皮下注射治疗糖尿病合并甲亢。Objective To investigate the clinical effect of insulin pump in treatment of diabetes mellitus complicated with hyperthyroidism.Methods 31 diabetes mellitus cases complicated with hyperthyroidism treated from January 2013 on were selected （study group）.All the patients were treated with continuous subcutaneous insulin injection by insulin pump.Among the cases,21 were male,10 were female,aged between 24 -81years old （average 28.3 ±15.6）.The course of disease was 14 years （average 4.6 ±5.2 years）.The cases were compared with those treated with intermittent subcutaneous injection of insulin（control group） in terms of FBG,PBG2h,daily average insulin dosage （u/d）,standard time of glucose value （h）,and the rate of hypoglycemia （%）.Results Before treatment,the FBG and PBG2h levels in the two groups showed no significant difference（P 〉0.05）.After treatment,however,the FBG and PBG2h levels were lower in the study group than in the control group（P 〈0.05）.Besides,the study group＇s daily average insulin dosage,standard time of glucose value,incidence of hypogly-cemia were lower than the control group（P 〈0.05）.Conclusion The clinical effect of continuous subcutaneous insulin injec-tion by insulin pump is better than that of intermittent subcutaneous injection of insulin for treatment of diabetes mellitus com-plicated with hyperthyroidism.

关 键 词：糖尿病 甲状腺功能亢进 胰岛素泵 

分 类 号：R581.1[医药卫生—内分泌] R587.1[医药卫生—内科学]