脂必泰胶囊与阿托伐他汀钙对老年血脂异常患者血脂和炎症因子的影响  

Influence of Zhibitai Capsule Combined with Atorvastatin Calcium Tablet on Blood Lipid and Inflammatory Factors in Elder Patients with Dyslipidemia

作　　者：王朝阳[1] 陈辉[2] 

机构地区：[1]湖北中医药大学基础医学院,武汉430065 [2]湖北中医药大学体育部,武汉430065

出　　处：《医药导报》2015年第8期1047-1049,共3页Herald of Medicine

基　　金：湖北省教育厅科学技术研究项目(Q20112005)

摘　　要：目的观察脂必泰胶囊与阿托伐他汀钙对老年血脂异常患者血脂和炎症因子的影响。方法选择老年血脂异常患者64例,随机分为对照组和治疗组,每组32例。对照组患者睡前口服阿托伐他汀钙片10 mg·d-1,治疗组患者在对照组基础上加服脂必泰胶囊(每次240 mg,bid)。均治疗6周。分别于治疗前后检测两组患者血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平。结果与对照组治疗后比较,治疗组患者治疗后血清TC[(5.18±0.57)mmol·L-1比(5.73±0.65)mmol·L-1]、TG[(1.52±0.43)mmol·L-1比(1.86±0.48)mmol·L-1]、LDL-C[(3.36±0.48)mmol·L-1比(3.85±0.53)mmol·L-1]、TNF-α[(5.37±2.21)ng·L-1比(7.63±2.59)ng·L-1]和IL-6[(12.27±2.75)ng·L-1比(15.63±2.92)ng·L-1]水平均显著降低(均P<0.01),HDL-C[(1.26±0.25)mmol·L-1比(1.13±0.23)mmol·L-1]水平显著升高(P<0.05)。结论脂必泰胶囊联合阿托伐他汀钙治疗老年血脂异常,不仅有调脂作用,还具有降低患者血清TNF-α和IL-6水平、抑制炎症反应作用。Objective To observe the influence of Zhibitai capsule combined with atorvastatin calcium tablet on blood lipid and inflammatory factors in elder patients with dyslipidemia. Methods Sixty-four eider patients with dyslipidemia were randomly divided into control group and treatment group, with 32 cases in each group.Patients of the control group were treated with atorvastatin calcium tablet （10 mg, qd, bedtime administration）, while patients in the treatment group were given Zhibitai capsule （240 mg, bid） for 6 weeks. Serum levels of TC, TG, HDL-C, LDL-C, tumor necrosis factor-alpha （TNF-α） and interleukin-6 （IL-6） were measured before and after treatment. Results After treatment, compared with the control group, TC [ （5.18±0.57） mmol · L^-1 vs.（5.73±0.65）mmol· L^-1], TG [ （1.52±0.43） mmol · L^-1 vs.（1.86±0.48） mmol · L^-1 ], LDL-C [ （3.36±0.48） mmol · L^-1 vs.（3.85±0.53）mmol · L^-1], TNF-α[ （5.37±2.21） ng · L^-1vs.（7.63±2.59） ng · L^-1] and IL-6 [ （12.27±2.75） ng· L^-1 vs.（15.63±2.92） ng· L^-1 ] were significantly deereased （P〈0.01 for all） ; however, HDL-C [ （ 1.26± 0.25 ） mmol ·L^-l vs. （ 1.13± 0.23 ） mmol · L^-1 ] was significantly increased in the patients of treatment group （ P〈 0.05 ）. Conclusion Zhibitai capsule combined with atorvastatin calcium tablet may not only regulate blood lipid level, but also decrease serum tumor necrosis factor-alpha and interleukin-6 so as to inhibit inflammation reaction in elder patients with dyslipidemia. KEY WORDS Zhibitai capsule;Atorvastatin calcium tablet;Dyslipidemia;Tumor necrosis faetor-alpha;Interleukin-6

关 键 词：脂必泰胶囊 阿托伐他汀钙片 血脂异常 肿瘤坏死因子-Α 白细胞介素-6 

分 类 号：R972.6[医药卫生—药品] R54[医药卫生—药学]