慢性乙型肝炎疾病静止期与炎性期红细胞CR1数量及黏附活性变化的临床研究  

Expression of erythrocyte CR1 in inflammatory activity and resting stage of chronic hepatitis B

作　　者：刘晓燕[1] 辛绍杰[1] 胡瑾华[1] 陈琰[1] 陈婧[1] 肖珑[1] 童晶晶[1] 关崇丹 严立龙 王海滨[2] 

机构地区：[1]解放军第302医院肝衰竭诊疗与研究中心,北京100039 [2]解放军第302医院临床检验医学中心,北京100039

出　　处：《中华临床医师杂志（电子版）》2015年第14期15-17,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的明确CR1在HBV慢性感染患者炎性期与静止期外周血红细胞表达变化及临床意义。方法应用流式细胞术检测HBV慢性感染不同人群外周血红细胞CR1(ECR1)的表达量;应用红细胞天然免疫黏附肿瘤细胞的测定方法检测ECR1分子黏附活性:以5个或以上红细胞黏附1个肿瘤细胞为一个结合单位,计算黏附率。结果慢性乙型肝炎静止期患者ECR1表达量及黏附活性均较炎症活动期患者高,有统计学差异(P<0.05);乙型肝炎肝硬化患者静止期明显高于活动期(P<0.05)。结论 ECR1表达量及黏附活性在HBV感染所致慢性肝病患者炎症活动期下降;ECR1与炎性活动可能有密切关系。Objective To study the expression and clinical significance of erythrocyte CR1 in patients with HBV infected liver diseases. Methods Venous blood was extracted f^r60 patients with liver disease, including chronic hepatitis, cirrhosis, and HBV-ACLF. Flow cytometry was used to study the expression of CR1 in patients with HBV infected liver diseases. RBC-C3bRR （RCR） was used for detection of CR1 immunity function. One tumor cell rounded by at least five red cells was used as a rosette to calculate the ratios. Results Our study showed CR1 expression on erythroeyte and adhesion activity in chronic active hepatitis B patients was significantly lower than in chronic non-active hepatitis B patients （P〈0.05）. In hepatitis B liver cirrhosis patients CR1 expression on erythroeyte and adhesion activity bad the Same result. Conclusion Expression and adhesion activity of ECR1 has correlated with the activity of intrahepatic inflammation. ECR1 may be related to hepatitis.

关 键 词：红细胞CR1 肝炎病毒 乙型 慢性肝病 

分 类 号：R512.62[医药卫生—内科学]