雾化吸入高渗盐水联合布地奈德、小剂量肝素治疗儿童喘息性疾病的效果观察  

Effect observation of atomization inhalation hypertonic saline,budesonide and low-dose heparin in the treatment of children asthmatic disease

作　　者：邓瑜琼 罗敏[1] 方小平[1] 周萍[1] 李起涛 刘淑红[1] 

机构地区：[1]江西省兴国县人民医院儿科,江西兴国342400

出　　处：《中国当代医药》2015年第22期133-135,共3页China Modern Medicine

基　　金：江西省卫生计生委科技计划课题(20154056)

摘　　要：目的探讨儿童喘息性疾病的药物联合治疗效果。方法选择2012年1月~2013年12月在本院住院治疗并符合本研究纳入标准的152例喘息性疾病患儿作为研究对象,将其按照随机数字表法分为A组（n=52）、B组（n=49）及C组（n=51）。A组行雾化吸入高渗盐水联合布地奈德、小剂量肝素治疗;B组行雾化吸入高渗盐水联合布地奈德治疗;C组行单纯雾化吸入高渗盐水治疗。记录3组患儿的临床症状消失时间、住院时间以及治疗有效率。结果 A、B组临床症状消失时间和住院时间均显著短于C组（P〈0.05）,且A组哮鸣音消失时间显著短于B组（P〈0.05）,但A、B两组的气促、湿啰音消失时间和住院时间差异无统计学意义（P〉0.05）。A、B组的治疗总有效率均显著高于C组（P〈0.05）,且A组高于B组,但差异无统计学意义（P〉0.05）。结论雾化吸入高渗盐水联合布地奈德、小剂量肝素治疗儿童喘息性疾病安全有效。Objective To investigate the effect of drug combination therapy for children with asthmatic disease. Meth-ods 152 cases of children with asthmatic diseases hospitalized in our hospital and met the inclusion criteria from Jan-uary 2012 to December 2013 were selected as research object.They were divided into group A（n=52）,group B（n=49） and group C （n=51） according to random number table method.Group A was treated with hypertonic saline,budesonide and low-dose heparin,group B was treated with hypertonic saline and budesonide,group C was treated with hypertonic saline.The clinical symptoms disappear time,hospital stays and effective rate was retrospectively analyzed. Results The clinical symptoms disappear time,hospital stays in group A and B was significantly shorter than those in group C （P〈0.05）.The time of anhelation and moist rales disappear in group A was shorter than that in group B,but there was no statistically significant difference （P〉0.05）.The effective rate in group A and B was significantly higher than that in group C （P〈0.05）.In addition,the effective rate in group A was higher than that in group B,but there was no statistically significant difference（P〉0.05）. Conclusion It was effective and safety for the treatment of children asthmatic disease by using the application of atomization inhalation hypertonic saline,budesonide and low-dose heparin.

关 键 词：雾化吸入 高渗盐水 布地奈德 肝素 儿童喘息性疾病 

分 类 号：R725.6[医药卫生—儿科]