240例儿童哮喘危险因素分析  

Analysis of the associated factors of asthma in children

作　　者：代文霞[1,2] 张英旭[1,2] 谭志红[1,2] 刘青[1,2] 刘英[1,2] 和勇[1,2] 夏艳艳[1,2] 

机构地区：[1]北京市海淀医院 [2]北京大学第三医院海淀院区儿科,北京100080

出　　处：《中日友好医院学报》2015年第4期214-216,共3页Journal of China-Japan Friendship Hospital

摘　　要：目的:探讨儿童支气管哮喘的相关危险因素,为儿童哮喘的防治提供参考。方法:选取240例哮喘患儿为研究对象,同期来院就诊非哮喘儿童230例作为对照。通过问卷调查和实验室检查,追溯哮喘病史,寻找哮喘发病的相关因素,并随访其治疗情况。结果:单因素分析表明,2组间在个人过敏史、家族过敏史、家族哮喘史、特应性体质、EOS计数升高、总IGE升高、皮肤点刺阳性、呼吸道感染、天气变化上存在显著性差异(均P<0.01)。多因素分析表明,个人过敏史、家族过敏史、家族哮喘史、特应性体质、EOS计数升高、总IGE升高、皮肤点刺阳性和呼吸道感染是儿童发生哮喘的独立危险因素(P<0.01)。结论:遗传因素与哮喘的发病密切相关,特应性体质是儿童哮喘的危险因素,生物、环境因素是哮喘的诱因。Objective ：To explore the associated factors of asthma in children.Methods：A total of 240 hospital- ized children with asthma and 230 children without asthma from outpatient department were compared.Ques- tionnaires and laboratory tests were used to determine the associated factors ofasthma.Results：There were sta- tistically significant differences in the proportions of personal and family history of allergy and asthma ,idiosyn- crasies, higher eosinophil count, higher total immunoglobulin E （IGE）,a positive skin prick test, respiratory tract infections,and the weather changes prior to onset between the two groups（all P〈0.01）.The result of mul- tivariate regression analysis showed that personal and family history of allergies,idiosyncrasies, higher EOS count,higher total IGE,a positive skin prick test,and respiratory tract infections were independent associated factors of asthma in children （P〈0.01）.Conclusion：Personal and family history of allergies,idiosyncrasies were associated with asthma in children,intervention of biological and environmental triggers may prevent the onset of asthma.

关 键 词：儿童 危险因素 哮喘 

分 类 号：R725.6[医药卫生—儿科]