长期重复高压氧暴露对氧化应激的影响  

Influences of long-term and repetitive exposure to hyperbaric oxygen on oxidative stress

作　　者：龙颖 谭杰文[2] 邓宝雯[2] 卢瑜 梅秀芳 彭锐 

机构地区：[1]广东省深圳市人民医院,518020 [2]中山大学孙逸仙医院,广州市510600

出　　处：《实用医学杂志》2015年第16期2666-2668,共3页The Journal of Practical Medicine

基　　金：深圳市科技计划项目(编号:201203138)

摘　　要：目的:探讨长期0.18 MPa氧分压对机体氧化应激指标的影响。方法:观察16例健康志愿者、58例突发性耳聋患者分别在常压下、0.18 MP氧分压下长期重复高压氧(HBO)暴露时,周围静脉血中氧化应激指标(丙二醛、高级氧化蛋白产物和超氧化物歧化酶)的变化。结果:连续5、10、20、30次0.18 MPa的HBO暴露后(1次/d,5次/周),健康志愿者对照组与突发性耳聋组观察对象的血清内丙二醛、高级氧化蛋白产物和超氧化物歧化酶与治疗前、与突发性耳聋综合治疗相比,差异均无统计学意义(P>0.05)。结论:长期低压力(0.18 MPa)HBO暴露对氧化应激正常的健康对象和突发性耳聋患者没有影响;对氧化应激反应异常者的影响需进一步研究。Objective To evaluate the levels of oxidative stress in patients undergoing long-term and repetitive exposure to hyperbaric oxygen （HBO） treatment. Methods 16 healthy volunteers and 58 patients with sub-acute sudden hearing loss （SHL） exposed to HBO were included in the study. Oxidative stress indices （malondialdehyde, MDA, advanced oxidation protein products, AOPP; superoxide dismutase, SOD） were measured in peripheral blood samples collected at the 5th , 10th , 20th and 30th HBO treatments sessions （PO2 0.18 MPa, 1 session per day and 5 sessions per week） and under normal ambient pressure respectively. Results Mter 5th , 10th , 20th and 30th sessions of HBOT, no relevant differences in these three indices were detected compared to pre-HBO exposure, between healthy volunteers （P 〉 0.05）. Conclusions The long-term repetitive HBO treatment for 0.18 MPa of PO2 and 30 sessions could not affect in particular the response of the oxidative stress in healthy persons and patients with sub-acute SHL. The influence on three indices of patients with abnormal situation of oxidative stress undergoing lower pressure of HBO （0.18 MPa） is under investigation.

关 键 词：高压氧 氧化应激 高级氧化蛋白产物 丙二醛 超氧化物歧化酶 

分 类 号：R459.6[医药卫生—治疗学]