IL-1β-511和IL-10-592基因多态性与尘肺及尘肺合并结核易感性的关系  

Relationship of IL-1β-511 and IL-10-592 polymorphisms with susceptibility of pneumoconiosis and pneumoconiosis combined with tuberculosis

作　　者：麦志丹[1] 李小萍[1] 梁梅[1] 潘沛江 梁冰玉[2] 陈荣凤[2] 韦琳[1] 

机构地区：[1]广西壮族自治区职业病防治研究院,南宁市530021 [2]广西医科大学公共卫生学院,南宁市530021

出　　处：《广西医学》2015年第6期749-751,共3页Guangxi Medical Journal

基　　金：广西科学研究与技术开发计划项目(桂科攻1140003B-83)

摘　　要：目的探讨白细胞介素(IL)-1β-511和IL-10-592位点基因多态性与尘肺、尘肺合并结核遗传易感性的关系。方法应用聚合酶链反应-限制性片断长度多态性技术检测103例尘肺患者、51例尘肺合并结核病患者及60例粉尘接触者IL-1β-511和IL-10-592位点基因多态性。结果 3组IL-1β-511、IL-10-592位点基因型和等位基因分布比较,差异无统计学意义(P>0.05)。结论 IL-1β-511、IL-10-592位点基因多态性与尘肺、尘肺合并结核易感性可能无关。Objective To study the relationship of interleukin（IL）-1β-511 and IL-10-592 polymorphisms with susceptibility of pneumoconiosis and pneumoconiosis combined with tuberculosis.Methods Polymerase chain reaction-restriction fragment length polymorphism was used to detect IL-1β-511 and IL-10-592 polymorphisms in 103 pneumoconiosis patients,51 pneumoconiosis patients with tuberculosis and 60 dust-exposed cases.Results There was no significant difference in the genotype or allele of IL -1β-511,IL-10-592 locus among three groups（P 〉0.05）.Conclusion IL-1β-511 and IL-10-592 polymorphisms might not be associated with susceptibility of pneumoconiosis or pneumoconiosis combined with tuberculosis.

关 键 词：尘肺 结核病 基因多态性 白细胞介素 

分 类 号：R135.2[医药卫生—劳动卫生]