3种抗真菌药治疗儿童真菌性肺炎的疗效对比研究  

Comparative study on curative effects among three kinds of antifungal on children with fungal pneumonia

作　　者：谢丽冰[1] 唐柳平[1] 

机构地区：[1]广西医科大学第四附属医院儿科,广西柳州545005

出　　处：《西南国防医药》2015年第8期853-856,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨伊曲康唑、氟康唑、伏立康唑对儿童真菌性肺炎的临床疗效,为临床提供参考。方法选择我院2010年12月～2014年12月收治的150例儿童真菌性肺炎患者资料进行分析,根据不同治疗方案将患者分为伊曲康唑组、氟康唑组、伏立康唑组,比较3组治疗后的疗效、临床症状改善情况等指标。结果伏立康唑组治疗后痰培养白色念珠菌的平均菌数、隐球菌的平均菌数,显著高于伊曲康唑组和氟康唑组（P〈0.05）;伏立康唑组治疗后毛霉菌的平均菌数,显著低于伊曲康唑组和氟康唑组（P〈0.05）;伊曲康唑组与氟康唑组相比,并发症发生率差异不显著（P〉0.05）;伏立康唑组并发症发生率为26.1%,显著高于伊曲康唑组和氟康唑组（P〈0.05）;伊曲康唑组治疗总有效率为89.1%,氟康唑组为91.8%,伏立康唑组为91.3%,3组相比差异无统计学意义（P〉0.05）。结论采用伊曲康唑、氟康唑、伏立康唑治疗儿童真菌性肺炎均可获得很好的疗效,治疗时应该根据患儿真菌谱及抗真菌药敏试验等选择合适药物,以提高临床疗效。Objective To investigate the clinical curative effects of itraconazole, fluconazol, and voriconazole on children with fungal pneumonia in order to provide reference for clinical practice. Methods Analysis was made in the clinical data of 150 children with fungal pneumonia hospitalized between December 2010 and December 2014. According to different treatment plans, those patients were divided into itraconazole, fluconazol, and voriconazole groups. Comparison was made in the curative effects and improvement in clinical symptoms among the three groups after the treatment. Results After the treatment, the average numbers of candida albicans and cryptococcous in sputum culture in voriconazole group were significantly higher than those in the other two groups （P 〈 0.05）; the average number of mlod fungus in voriconazole group was significantly lower than that in the other two groups （P 〈 0.05）. There was no significant difference in the incidence of complications between itraconazole and fluconazol groups （P 〉 0.05）. The incidence of complication in voriconazole group was 26.1%, which was significantly higher than those in the other two groups （P 〈 0.05）. The total effective rate of itraconazole, fluconazol, voriconazole groups was 89.1%, 91.8%, and 91.3%, respectively. There was no significant difference among the three groups （P 〉 0.05）. Conclusion The treatment with itraconazole, fluconazol, and voriconazole on children with fungal pneumonia can achieve good curative effects. During the treatment, proper medicine should be selected according to the children＇s antimicrobial spectrum and drug susceptibility testing results in order to improve the clinical curative effect.

关 键 词：伊曲康唑 氟康唑 伏立康唑 儿童 真菌性肺炎 疗效 

分 类 号：R379[医药卫生—病原生物学]