DCC法合成烟酸对乙酰氨基苯酯及其晶体结构表征  

Synthesis and Crystal Structures of( 4-Acetamidophenyl ) pyridine-3-carboxylate via DCC Condensation

作　　者：刘振香[1] 王琦[1] 陈鋆[1] 罗小会[1] 

机构地区：[1]金华职业技术学院制药与材料工程学院,浙江金华321007

出　　处：《化学试剂》2015年第8期762-764,共3页Chemical Reagents

基　　金：浙江省教育厅基金资助项目(2014YB019;FX2013215);2014年浙江省大学生科技创新活动计划暨新苗人才计划项目(2014R465011)

摘　　要：烟酸与对乙酰氨基苯酚在无水丙酮溶液中,在DCC作脱水剂、DAMP作催化剂作用下,常温反应3 h,收率82.1%,操作简单,条件温和,收率高。同时对其进行红外、核磁和X-射线衍射测定,结果表明,其分子式为C14H12N2O3,分子量为256.26,a=0.554 7(11)nm,b=2.733 6(5)nm,c=0.830 30(17)nm,α=90°,β=94.14(3)°,γ=90°,属于单斜晶系C/c空间群。In the anhydrous acetone solution, （4-acetamidophenyl） pyridine-3-carboxylate was synthesized by the reaction of 3-pyridinecarboxylie acid reacted with 4-acetaminophenol in the presence of DCC which was used as dehydrating agent and DMAP which was used as catalyst for 3 h at room temperature. The yield reaches 82. 1% and the result shows the operation process is simple and fast. The crystal structure was confirmed by X-ray diffraction,the result showed that the molecular formula is C14 H12 NEO3,Mr =256.26,a=0.554 72（11） nm,b =2.733 6（5） nm,c=0.830 30（17） nm,α=90°,β=94.14（3）°,γ=90°,belongs to the monoclinic system and C/c space group.

关 键 词：烟酸对乙酰氨基苯酯 合成 DCC 晶体结构 

分 类 号：O621.3[理学—有机化学]