肺结核患者外周血sIL-2R、IL-6、IL-8、IL-10及TNF-α的检测意义  

Significance of sIL-2R,IL-6,IL-8,IL-10 and TNF-α expression in peripheral blood of patients with tuberculosis

作　　者：朱晓燕[1] 陈慧[1] 徐俊驰[1] 吴妹英[1] 陈兴年[1] 胥萍[1] 

机构地区：[1]苏州市第五人民医院,江苏苏州215007

出　　处：《临床肺科杂志》2015年第9期1564-1566,共3页Journal of Clinical Pulmonary Medicine

基　　金：江苏省卫生厅资助项目(No KF200974)

摘　　要：目的分析未抗痨治疗的结核患者及已经有效治疗的患者s IL-2R、IL-6、IL-8、IL-10及TNF-α表达的差异,以探讨上述指标的变化及意义。方法采用免疫化学发光法检测未抗结核治疗患者(A组)、抗结核治疗有效患者(B组)及健康组(C组)上述指标的表达水平,并比较各组差异。结果 A组C组相比较,均明显升高(P<0.01)。B组s IL-2R和IL-6的含量较A组明显下降,分别为(509.41±96.52)U/ml vs(1207.09±105.33)U/ml和(8.91±3.22)pg/ml vs(37.84±15.46)pg/ml(P<0.01);IL-8和TNF-α在B组中的含量较A组明显下降,分别为(12.78±3.69)pg/ml vs(23.82±5.67)pg/ml和(14.33±6.82)pg/ml vs(32.41±11.66)pg/ml(P<0.05);而IL-10水平未发生明显变化。结论肺结核病患者s IL-2R、IL-6、IL-8、TNF-α水平明显增加,抗结核治疗后上述因子水平明显降低,初步提示s IL-2R、IL-6、IL-8、TNF-α表达水平与结核活动程度相关,有望进一步作为评价肺结核活动程度的指标。Objective To analyze the expression difference of sIL-2R, IL-6, IL-8, IL-10 and TNF-α in pe-ripheral blood between patients with pulmonary tuberculosis not given anti-tuberculosis treatment and those who al-ready recovered after anti-tuberculosis treatment. Methods The expression of sIL-2R, IL-6, IL-8, IL-10 and TNF-α in peripheral blood were detected by immune chemical luminescence method in TB patients not given anti-tubercu-losis treatment （the group A）, those who already recovered after anti-tuberculosis treatment （the group B） and the healthy controls （the group C）. Results The levels of serum s IL-2R, IL-6, IL-8, IL-10 and TNF-α were signifi-cantly higher in the group A than in the group C （P〈0. 01）. The levels of serum sIL-2R and IL-6 decreased more significantly in the group B than in the group A, which were respectively （509. 41 ± 96. 52） U/ ml vs （1207. 09 ± 105. 33） U/ ml and （8. 91 ± 3. 22） vs （37. 84 ± 15. 46） pg/ ml （P〈0. 01）. The levels of serum IL-8 and TNF-αwere significantly lower in the group B than in the group A, which were respectively （12. 78 ± 3. 69） pg/ ml vs （23. 82 ± 5. 67） pg/ ml and （14. 33 ± 6. 82） pg/ ml vs （32. 41 ± 11. 66） pg/ ml （P〈0. 05）. The level of IL-10 showed no significant difference between the group A and the group B. Conclusion The levels of sIL-2R and IL-6, IL-10, IL-8 and TNF-α increase significantly in pulmonary tuberculosis patients, and they decrease obviously after anti-tuberculosis treatment, which indicates that those cytokines may be related with the activity of pulmonary tuber-culosis.

关 键 词：肺结核 可溶性白介素-2受体 白介素-6 白介素-8 白介素-10 肿瘤坏死因子-α 

分 类 号：R521[医药卫生—内科学]