阿莫西林/克拉维酸钾联合左氧氟沙星治疗耐多药肺结核的临床效果  

Clinical efficacy of amoxicillin/clavulanate potassium combined with levofloxacin in the treatment of multi-drug resistant pulmonary tuberculosis

作　　者：童维佳[1,2] 王永庆[1] 

机构地区：[1]南京医科大学第一附属医院江苏省人民医院,江苏南京210029 [2]南京市胸科医院药学部

出　　处：《临床肺科杂志》2015年第9期1602-1604,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的 :观察并评价阿莫西林/克拉维酸钾联合左氧氟沙星在治疗耐多药肺结核(MDR-TB)的疗效。方法将80例复治涂阳耐多药肺结核患者随机分为对照组40例和治疗组40例;治疗方案:对照组以左氧氟沙星为主,联合对氨基水杨酸异烟肼、盐酸乙胺丁醇、利福喷丁、吡嗪酰胺,治疗组以阿莫西林/克拉维酸钾、左氧氟沙星为主,联合用药同对照组,所有病例疗程均为12个月。结果至疗程结束,对照组痰菌阴转率为52.50%,治疗组痰菌阴转率为75.00%,治疗组痰菌阴转率明显高于对照组(P<0.05);对照组空洞闭合有效率及病灶吸收有效率都为55.00%,治疗组则均为77.50%,治疗组空洞闭合有效率及病灶吸收有效率均明显高于对照组(P<0.05);两组不良反应皆低,且无差异(P>0.05)。结论对于耐多药肺结核,用阿莫西林/克拉维酸钾联合左氧氟沙星治疗利于痰菌阴转和病变吸收好转,药品不良反应低,具有推广价值。Objective To observe and evaluate the clinical effect of amoxicillin/ clavulanate potassium com-bined with levofloxacin in the treatment of multi-drug resistant pulmonary tuberculosis （MDR-TB）. Methods 80 re-treated smear positive patients with multi-drug resistant pulmonary tuberculosis were randomly divided into the control group and the treatment group, 40 cases in each group. The control group was treated with levofloxacin combined with pasiniazid, ethambutol hydrochloride, rifapentine and pyrazinamide, and the treatment group was treated with amoxi-cillin/ clavulanate potassium and levofloxacin, combined with pasiniazid, ethambutol hydrochloride, rifapentine and pyrazinamide. All patients were treated for 12 months. Results At the end of the treatment, the sputum negative conversion rate was 52. 50% in the control group, and 75% in the treatment group （P〈0. 05）. The cavity closure and lesion absorption was 55% in the control group, which was obviously lower in the treatment group （77. 50% ） （P〈0. 05）. There was no significant difference in adverse reaction between the two groups（P〉0. 05）. Conclusion Amoxicillin/ clavulanate potassium combined with levofloxacin regimen can improve the sputum negative conversion and lesions absorption,with low adverse drug reaction in the treatment of multi-drug resistant pulmonary tuberculosis.

关 键 词：阿莫西林/ 克拉维酸钾 左氧氟沙星 耐多药肺结核 

分 类 号：R521[医药卫生—内科学]