呼出气冷凝液中8-异前列腺素水平检测对咳嗽变异性哮喘的临床意义  

Clinical significance of 8-isoprostane in exhaled breath condensate of patients with cough variant asthma

作　　者：李志莹[1] 徐健[1] 陈济明[1] 李一禄[1] 聂莉[1] 陈延伟[1] 

机构地区：[1]广东医学院附属南山医院呼吸内科,广东深圳518052

出　　处：《临床肺科杂志》2015年第9期1633-1635,共3页Journal of Clinical Pulmonary Medicine

基　　金：深圳市科技计划项目(No 201203212)

摘　　要：目的探讨8-异前列腺素检测对诊治咳嗽变异性哮喘(CVA)的临床意义。方法选取50例CVA患者和30例健康对照纳入研究,所有受试者测定呼出气冷凝液中8-异前列腺素水平并进行肺功能检测。结果与健康人群相比,CVA患者EBV中8-iso-PG水平显著升高(P<0.01);治疗前后比较,CVA患者EBV中8-iso-PG水平明显降低(P<0.01),而FEV1%检测差异无统计学意义。EBV中8-iso-PG水平与FEV1%检测值之间无相关性(r=-0.17,P>0.05)。结论 EBC中8-iso-PG检测可直观反映CVA患者存在的气道氧化应激状态,并能较好的预测治疗敏感性,从而有助于CVA患者的早期诊断和疗效预判。Objective To investigate the clinical significance of the detection of 8-isoprostane in exhaled breath condensate （EBC） in patients with cough variant asthma （CVA）. Methods 50 patients with CVA and 30 cases of healthy controls were enrolled. The level of 8-iso-PG in EBC was measured in all subjects, and their FEV1%value was evaluated. Results The level of 8-iso-PG in EBC in patents with CVA were significantly higher than that in the healthy controls （P〈0. 01）. The level of 8-iso-PG in EBC decreased obviously after the treatment （ P〈0. 01）, while the value of FEV1% showed no significant difference after the treatment. There was no significant cor-relation between 8-iso-PG and FEV1% （ r = - 0. 17, P〉0. 05）. Conclusion 8-iso-PG detection in EBC canreflect the airway oxidative stress response existed in CVA, and 8-iso-PG test can be used as an objective indicator for early diagnosis and the healing efficacy of CVA disease.

关 键 词：咳嗽变异性哮喘 8-异前列腺素 呼出气冷凝液 

分 类 号：R562.25[医药卫生—呼吸系统]