脾氨肽干预对传染性单核细胞增多症患儿T细胞亚群的影响  

The Influence of Spleen Aminopeptide on T Lymphocyte Subsets of Infectious Mononucleosis

作　　者：孙飞[1] 陆晓萍[1] 潘顺陆[1] 

机构地区：[1]浙江省嘉兴市第一医院,浙江嘉兴314000

出　　处：《儿科药学杂志》2015年第8期4-6,共3页Journal of Pediatric Pharmacy

摘　　要：目的:观察脾氨肽干预对传染性单核细胞增多症(IM)患儿T细胞亚群的影响,探讨其对IM患儿的免疫调节作用。方法:选取2011年6月至2014年5月在我院住院的IM患儿102例,分为常规治疗组52例和脾氨肽干预组50例。两组患儿均给予对症处理,同时给予更昔洛韦每次5 mg/kg,每12 h一次静脉滴注,治疗1周;脾氨肽干预组加用口服脾氨肽冻干粉每次2 mg,每天一次,连服10 d。以我院同期健康体检儿童26例作为正常对照组,观察常规治疗组和脾氨肽干预组患儿外周血T细胞亚群的变化情况。结果:治疗前两组患儿CD4+、CD16+CD56+、CD4+/CD8+均低于正常对照组(P<0.01),CD3+、CD8+均高于正常对照组(P<0.01);治疗后两组患儿T细胞亚群异常情况均有所恢复,且脾氨肽干预组CD4+、CD4+/CD8+上升幅度及CD3+、CD8+下降幅度均大于常规治疗组(P<0.05),而CD16+CD56+与常规治疗组比较差异无统计学意义(P>0.05)。结论:IM患儿存在T淋巴细胞免疫功能低下,脾氨肽干预可促进IM患儿细胞免疫功能恢复。Objective： To investigate the influence of spleen aminopeptide on T lymphocyte subsets in children with infectious mononucleosis. Methods： A total of one hundred and two children with infectious mononucleosis were divided into conventional therapy group （52 cases） and spleen aminopeptide interventional group （50 cases）, and 26 healthy children as control group. The children in conventional therapy group were treated with routine drugs only, while the others in spleen aminopeptide interventional group were treated with spleen aminopeptide for ten days on this basis. Results： The percentages of CD4＋, CD16＋ CD56＋ and the ratio of CD4＋/CD8＋ in conventional therapy group and spleen aminopeptide interventional group were less than control group, the percentages of C D3＋and C D8＋ were higher than control group before treatment （P〈0.01）. After 3 weeks of treatment, the percentages of C IM＋, CD16＋CD56＋ and the ratio of CD4＋/CD8＋ in the two groups of children were significantly increased than before （P〈0.01）, the percentages of CD3＋ and CD8＋ were significantly decreased than before （P〈0.01）, the magnitude of rise and decline in spleen aminopeptide interventional group were more obvious than those in conventional therapy group （P〈0.05）. The percentages of CD16＋ CD56＋ in had spleen aminopeptide interventional group no statistically significant difference with conventional therapy group （P〉0.05）. Conclusion： Spleen aminopeptide is an effective drug to improve the cellular immune for children with infectious mononucleosis.

关 键 词：脾氨肽 传染性单核细胞增多症 T淋巴细胞亚群 

分 类 号：R725.1[医药卫生—儿科]