不同剂量干扰素α1b雾化治疗小儿毛细支气管炎的疗效及安全性  

Effect and Safety of Interferon α1b Treatment of Bronchiolitis in Children

作　　者：黄云[1] 

机构地区：[1]江苏省泰兴市人民医院,江苏泰兴225400

出　　处：《儿科药学杂志》2015年第8期25-27,共3页Journal of Pediatric Pharmacy

摘　　要：目的:观察不同剂量干扰素α1b雾化治疗小儿毛细支气管炎的疗效及安全性。方法:随机选择在我院儿科住院治疗的毛细支气管炎患儿共240例,分为不使用重组人干扰素α1b组(对照组)、重组人干扰素α1b低剂量组(低剂量组)、重组人干扰素α1b高剂量组(高剂量组)各80例,比较三组患儿治疗有效率、临床症状改善情况及不良反应。结果:低剂量组总有效率93.75%,高剂量组总有效率95.00%,对照组总有效率81.25%,低剂量组、高剂量组与对照组比较差异均有统计学意义(P<0.05),但低剂量组与高剂量组疗效比较差异无统计学意义(P>0.05);低剂量组、高剂量组患儿症状、体征消失时间及住院时间均明显短于对照组(P<0.05),但低剂量组与高剂量组症状、体征消失时间及住院时间比较差异无统计学意义(P>0.05)。所有雾化干扰素的患儿均未发现明显不良反应。结论:雾化吸入干扰素α1b治疗小儿毛细支气管炎疗效显著,未发现明显不良反应,说明低剂量干扰素α1b雾化治疗更具有临床推广价值。Objective： To observe effect and safty of different doses of interferon al b atomization in treating children with bronchiolitis. Methods： Two hundred and forty children with bronchiolitis were divided into three groups randomly, including control group, low dose group and high dose group. The total effective rate of therapy, the clinical symptoms and adverse reactions were observed. Results： The total effective rate of low dose group was 93.75 %, 95.00% in the high dose group, 81.25 % in the control group, there were significant difference between low dose group and control group, high dose group and control group （ P 〈 0.05 ）, but there was no significant difference between low dose group and high dose group （P〉0.05）. The disappearance time of symptoms and signs were not difference between low dose group and high dose group （P〉0.05）. Conclusion： Recombinant human interferon otl b treatment of bronchiolitis can effectively increase the clinical efficacy and shorten the course of disease, is worthy of clinical popularization and application.

关 键 词：毛细支气管炎 重组人干扰素Α1B 不同剂量 雾化治疗 

分 类 号：R725.6[医药卫生—儿科]