热性惊厥患儿血气指标变化与BDNF、NSE、S100B表达水平的相关性分析  

Correlation between blood gas analysis and BDNF,NSE,S100B in children with febrile seizures

作　　者：赵丽梅[1] 赵玉萍[1] 高翠红[1] 肖凤艳[1] 张远枝[1] 

机构地区：[1]唐山市妇幼保健院,河北唐山063000

出　　处：《热带医学杂志》2015年第7期920-921,935,共3页Journal of Tropical Medicine

基　　金：河北省唐山市科技计划项目(14130244a)

摘　　要：目的分析热性惊厥患儿各血气指标的变化及血清中脑源性神经营养因子(BDNF)、神经元特异性烯醇化酶(NSE)和EF手型钙结合蛋白(S100B蛋白)的表达,分别探讨其与PCO2的相关性。方法采用血气分析仪检测热性惊厥患儿和对照组儿童的p H、PCO2、TCO2。用酶联免疫吸附试验检测两组儿童血清中BDNF、NSE、S100B的含量。结果热性惊厥组PCO2、TCO2及BDNF、NSE、S100B明显低于对照组,p H高于对照组,差异有统计学意义(P<0.05)。重度组PCO2与BDNF、NSE、S100B存在明显的相关性(P<0.01),而轻度组、对照组PCO2与BDNF、NSE、S100B未发现明显的相关性(P>0.05)。结论呼吸性碱中毒是引发热性惊厥的危险因素,血清BDNF、NSE、S100B水平可作为热性惊厥患儿疾病进展程度的早期指标。Objective To analyze the changes of blood gas index as well as BDNF, NSE and S100B in children with febrile seizures, and explore the correlation between BDNF, NSE, S100B and PCO2. Methods pH, PCO2 and TCO2 were detected with the blood gas analyzer. BDNF, NSE and S100B in serum were measured by ELISA. Results The levels of PCO2, TCO2 as well as BDNF, NSE and S100B in the febrile seizure group were significantly lower than those in the control group while the level of pH in the febrile seizure group were higher than that in the control group and both differences were statistically significant （P〈0.05）. Also there was a positive correlation between BDNF, NSE, SIOOB and PCO2 in the sever group while no correlations were found in the mild and control groups. Conclusion Respiratory alkalosis may be a risk factor for febrile seizures. And the levels of BDNF, NSE and SIOOB in serum of children with febrile seizures can be used as early indicators in the progression of febrile seizures.

关 键 词：热性惊厥 呼吸性碱中毒 血气分析 

分 类 号：R720.597[医药卫生—急诊医学]