100例新生儿血麻疹抗体水平调查  

Survey on the levels of measles antibodies of 100 infants

作　　者：曹丽[1] 侯红斌[1] 张瑞倚 陈妙芬[1] 方琼[1] 段利娜[1] 林宝妮[1] 

机构地区：[1]深圳市福田区疾病预防控制中心,广东深圳518040

出　　处：《热带医学杂志》2015年第7期978-981,共4页Journal of Tropical Medicine

基　　金：福田区卫生公益性科研项目(FTWS201335)

摘　　要：目的了解新生儿脐血麻疹抗体水平的影响因素,为科学制定预防麻疹措施、降低小月龄婴儿麻疹发病提供依据。方法采用ELISA法检测100名妊娠母亲外周静脉血与所生新生儿脐带血麻疹Ig G抗体水平,对研究对象进行问卷调查。结果新生儿脐带血麻疹Ig G抗体阳性率为96.00%,保护率为54.00%,几何抗体平均浓度(GMC)为1 162.16 m IU/ml。新生儿的性别、产重、产次等因素对脐带血麻疹Ig G抗体水平无影响(P>0.05)。妊娠母亲有麻疹发病史组的新生儿脐带血麻疹Ig G抗体保护率及GMC均高于有接种疫苗史组及无接种疫苗且无麻疹发病史组,差异有统计学意义(P<0.05)。结论建议对育龄妇女进行麻疹疫苗复种,以提高新生儿胎传抗体水平,从而降低小月龄婴儿麻疹发病率。Objective To understand the affecting factors of the serum measles antibody levels of the parturient women and their newborn infants, and provide basis for scientific prevention measure of measles and decrease the incidence rate of infants. Methods Serum samples of the 100 parturient women and their newborn infants were collected to test measles IgG antibody levels by measles enzyme linked immunosorbent assay （ELISA）. Questionnaires were conducted in the parturient women. Results Positive rate of measles antibody in the newborn infants was 96.00% with a protective rate of 54.00% and GMC of 1 162.16 mIU/ml. There were no statistical differences in serum measles IgG antibody levels of infant of different gender, weight and parity （P〉0.05）. An obvious higher serum measles antibody IgG levels and GMC of the infants whose mothers were previously infected with measles （x^2=6.2580, P〈0.05） than those whose mothers were immunized with measles vaccine and mothers were never infected or vaccinated （P〈0.05）. Conclusion This result suggested a booster measles vaccination of women at reproductive age may increase the serum measles antibody levels of infants and reduce the incidence of measles infection.

关 键 词：育龄妇女 新生儿 麻疹抗体 酶联免疫吸附试验 

分 类 号：R511.1[医药卫生—内科学]