鹿红颗粒治疗冠状动脉粥样硬化性心脏病合并心功能不全的临床研究  

Clinical Observations on Luhong Granule for Treatment of Coronary Atherosclerotic Heart Disease and Cardiac Insufficiency

作　　者：刘茜[1] 周华[1] 戎靖枫[1] 瞿惠燕[1] 薛金贵[1] 封舟[1] 黄牧华[1] 王佩[1] 徐基杰[1] 尹琴[1] 单艳梅 仇芩 

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《中西医结合心脑血管病杂志》2015年第7期867-870,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：上海市科委科研计划项目(No.11DZ1971701);上海市市级医院新兴前沿技术联合攻关项目(No.SHDC12012119)

摘　　要：目的观察鹿红颗粒治疗冠心病合并心功能不全的临床疗效及其改善慢性心力衰竭的作用。方法入选63例诊断为冠心病合并心功能不全,符合中医辨证为阳虚血瘀证患者,随机分为两组。对照组32例,脱落2例,完成观察病例30例,给予西药标准治疗;治疗组31例,脱落1例,完成观察病例30例,给予西药标准治疗基础上加鹿红颗粒治疗。3个月后观察患者中医症状评分、脑钠肽(BNP),超声心动图指标短轴缩短率(FS)、左室射血分数(LVEF)、每搏输出量(SV)、心功能分级以及明尼苏达生活质量评分、6分钟步行距离,评价鹿红颗粒对冠心病合并心功能不全的治疗作用。结果治疗组在改善患者中医症状、BNP水平、心超指标(LVEF、FS、SV)、心功能分级、生活质量及运动耐量均优于对照组。结论鹿红颗粒可改善冠心病合并心功能不全患者的中医症状,降低患者BNP水平,增强患者心脏收缩功能,增加心搏出量,改善心功能,提高患者的生活质量及运动耐量。Objective To observe the effects of Luhong granule（LHG） for treatment of coronary atherosclerotic heart disease（CAD） and cardiac insufficiency. Methods We choose 63 patients who were diagnosed of CAD with cardiac insufficiency and conformed to traditional Chinese medicine（TCM） yang deficiency syndrome and blood stasis syndrome. They were randomly divided into control group of 32 patients,2 cases fell off and 30 cases had completed, given the standard treatment of western medicine and treatment group of 31 patients, 1 cases fell off and 30 cases had completed, given standard western medicine treatment based up on Luhong granule. After 3 months we observed their TCM symptoms and scores, B - type natriuretic peptide （BNP）, Ultrasonic cardiogram （FS, LVEF, SV）, cardiac functional grading and Minnesota quality of life scores, 6 minute walk distance in order to evaluate the treatment of CAD with cardiac insufficiency of Luhong granule. Results The TGM symptom, BNP, ultrasonic cardiogram, cardiac functional grading and Minnesota quality of life scores, 6 minute walk distance in treatment group were better than that in control group. Conclusion Luhong granule can improve TCM symptom in patients with CAD and cardiac insufficiency and reduce BNP. Lu- hong granule can strengthen the cardiac systolic function, stroke volume and cardiac function of patients. Luhong granule can im- prove cardiac functional grading of patients and increase living quality and exercise tolerance of patients.

关 键 词：冠状动脉粥样硬化性心脏病 鹿红颗粒 心功能不全 

分 类 号：R259[医药卫生—中西医结合]