Hepatitis B among Inuit: A review with focus on Greenland Inuit  

作　　者：Karsten Fleischer Rex Stig Andersen Henrik Bygum Krarup 

机构地区：[1]Department of Internal Medicine, Queen Ingrid’s Hospital [2]Arctic Health Research Centre, Clinical Institute, Aalborg University Hospital [3]Greenland Centre for Health Research, Institute of Nursing and Health Science, University of Greenland [4]Department of Geriatric and Internal Medicine,Aalborg University Hospital [5]Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital

出　　处：《World Journal of Hepatology》2015年第9期1265-1271,共7页世界肝病学杂志（英文版）（电子版）

摘　　要：Hepatitis B virus(HBV) infection is a disease with a highly variable course. Chronic HBV infection may cause end-stage liver disease including cirrhosis and hepatocellular carcinoma, which is the 3rd most common cause of cancer related death due to the poor prognosis. The prevalence of HBV infection is low in many countries. Still, it remains important due to the potential consequences of the disease. HBV is endemic in the Arctic with serologic markers of chronic HBV infection in up to 29% of the population in some areas in Greenland. Interestingly, Inuit populations rarely show signs of liver disease despite the fact that around half of all Inuit has been exposed to HBV and around 8% of Inuit are chronically infected with HBV. These findings have been consistent in surveys conducted for more than four decades among Arctic Inuit. We thus review HBV infection in the Arctic with focus on Greenland Inuit and compared with Inuit in Canada, Alaska and Siberia. The aspects described include epidemiology and monitoring of the disease, as well as treatment and the risk of liver cancer.Hepatitis B virus （HBV） infection is a disease with ahighly variable course. Chronic HBV infection maycause end-stage liver disease including cirrhosisand hepatocellular carcinoma, which is the 3rd mostcommon cause of cancer related death due to the poorprognosis. The prevalence of HBV infection is low in manycountries. Still, it remains important due to the potentialconsequences of the disease. HBV is endemic in theArctic with serologic markers of chronic HBV infection inup to 29% of the population in some areas in Greenland.Interestingly, Inuit populations rarely show signs ofliver disease despite the fact that around half of allInuit has been exposed to HBV and around 8% of Inuitare chronically infected with HBV. These findings havebeen consistent in surveys conducted for more thanfour decades among Arctic Inuit. We thus review HBVinfection in the Arctic with focus on Greenland Inuit andcompared with Inuit in Canada, Alaska and Siberia. Theaspects described include epidemiology and monitoringof the disease, as well as treatment and the risk of livercancer.

关 键 词：HEPATITIS B HEPATITIS D Monitoring disease Prevention LIVER cancer INUIT GREENLAND ARCTIC 

分 类 号：R512.62[医药卫生—内科学]