前列腺增生症患者尿路感染细菌分布特点与耐药性分析  

Analysis on bacterial distribution and drug resistance of urinary tract infections in patients with prostate hyperplasia

作　　者：朱清[1] 张驰[2] 叶永生[3] 

机构地区：[1]南阳市中心医院泌尿外科,河南南阳473000 [2]南阳医学高等专科学校基础医学部,河南南阳473000 [3]南阳市中心医院妇科,河南南阳473000

出　　处：《中华医院感染学杂志》2015年第15期3440-3442,共3页Chinese Journal of Nosocomiology

基　　金：河南省科技厅科技基金资助项目(LX6253140)

摘　　要：目的探讨前列腺增生症患者尿路感染细菌分布特点及对临床常用抗菌药物的耐药性,为临床诊治前列腺增生症伴有尿路感染提供参考。方法选取2013年4-12月诊治的200例前列腺增生症伴有下尿路感染的患者,对中段尿进行细菌培养及药敏试验检测,分析其病原菌及耐药性,数据采用SPSS16.0软件进行统计分析。结果 84例患者尿液培养分离出病原菌,检出阳性率为42.00%,共分离出96株病原菌,以大肠埃希菌为主,共34株占35.42%;大肠埃希菌、肺炎克雷伯菌、奇异变形菌对庆大霉素、磺胺甲噁唑/甲氧苄啶耐药率均>50.00%;屎肠球菌、粪肠球菌对青霉素、氨苄西林、庆大霉素、左氧氟沙星、环丙沙星的耐药率>50.00%。结论引起前列腺增生症患者尿路感染革兰阴性菌以大肠埃希菌为主,革兰阳性菌以屎肠球菌及粪肠球菌为主,感染病原菌对青霉素类、头孢类、喹诺酮类等大多数抗菌药物有较高的耐药性。OBJECTIVE To investigate bacterial distribution characteristics and drug resistance to clinical commonly used antimicrobial drugs of urinary tract infections in patients with prostate hyperplasia ,so as to provide reference for clinical diagnosis and treatment of prostate hyperplasia accompanied by urinary tract infections .METHODS To‐tally 200 cases of prostatic hyperplasia with lower urinary tract infections during the period of Apr .-Dec .2013 were enrolled ,bacterial culture and drug susceptibility test were carried out on the midstream urine to analyze pathogens and their drug resistance .Data were statistically analyzed by the software SPSS 16 .0 .RESULTS The pathogenic bacteria were isolated by urine culture from 84 cases ,the positive rate was 42 .00% ,96 strains of path‐ogenic bacteria were isolated ,mainly including Escherichia coli （34 strains ,35 .42% ） .The resistance rates of E . coli , K lebsiella pneumoniae , Proteus mirabilis to gentamicin , sulfamethoxazole/trimethoprim were all 〉50 .00% .The resistance rates of Enterococcus f aecium ,Enterococcus f aecalis to penicillin ,ampicillin ,gentami‐cin ,levofloxacin ,and ciprofloxacin were all 〉50 .00% .CONCLUSION E .coli were the main gram‐negative bac‐teria and E . f aecium ,E . faecalis were the main gram‐positive bacteria causing urinary tract infections in patients with prostate hyperplasia .Pathogenic bacteria have high resistance to most antimicrobial drugs such as penicillins , cephalosporins ,and quinolones .

关 键 词：前列腺增生症 尿路感染 细菌 耐药性 

分 类 号：R378[医药卫生—病原生物学]