低三碘甲状腺原氨酸综合征与阳虚证候相关性研究  

Investigation of the correlation of low triiodothyronine syndrome and Yang deficiency syndrome in traditional Chinese medicine

作　　者：杨际平[1] 邵颖[1] 郭宗兵[1] 

机构地区：[1]山东省济宁市第一人民医院中医科,山东济宁272100

出　　处：《河北中医》2015年第9期1298-1302,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：2012年济宁市科技计划项目(编号:2012jnjz04)

摘　　要：目的探讨低三碘甲状腺原氨酸(T_3)综合征与阳虚证候的相关性,为低T_3阳虚证候的中医辨证提供依据。方法收集105例低T_3综合征患者为观察组,选择50例健康体检者为对照组,借助现代统计学方法,研究低T_3综合征与阳虚证候的相关性。结果观察组血清总三碘甲状腺原氨酸(TT_3)、游离三碘甲状腺原氨酸(FT_3)水平明显低于对照组(P<0.05),2组促甲状腺激素(TSH)水平虽均在正常范围内,但观察组与对照组相比较有所下降(P<0.05)。观察组出现频率最多的阳虚症状是畏寒肢冷(59.0%),其次为倦怠乏力(54.3%);观察组阳虚证(脾阳虚证、肾阳虚证、脾肾阳虚证)共87例,占82.86%,比例最高;脾肾阳虚证TT_3水平最低,与脾阳虚证、肾阳虚证及其他证型相比差异均有统计学意义(P<0.05);脾肾阳虚证阳虚症状积分明显高于脾阳虚证、肾阳虚证及其他证型(P<0.05)。结论低T_3综合征中阳虚证占首位,其中脾肾阳虚证、脾阳虚证所占比例最高,以畏寒肢冷为主要临床表现,血清甲状腺激素水平的变化有助于判断阳虚证型,低T_3综合征阳虚程度越重,T_3水平越低。Objective To investigate the correlation of low triiodothyronine （ T3 ） syndrome and Yang defi- ciency syndrome in traditional Chinese medicine （ TCM）, to provide a basis of Yang deficiency type of TCM syndrome differentiation. Methods 105 patients with low - T3 syndrome were collected in observation group. 50 health controls were collected in control group. The correlation of low T3 syndrome and yang deficiency syndrome was analyzed by modem statistics. Results The levels of serum total triiodothyronine （TT3 ） and free triiodothyronine （ FT3 ） in ob- servation group were obviously lower than those in control group （ P 〈 0.05 ）. The content of thyroid stimulating hor- mone （TSH） at normal level in two groups ,but the TSH content in observation group was decreased as compared with that in control group （ P 〈 0. 05 ）. The highest frequency syndrome of yang deficiency was extreme chilliness （59.0%） in observation gomp, next for lassitude and asthenia （54.3 % ）. There were 87 patients with yang deficien- cy syndrome （ spleen - yang deficiency syndrome, kidney - yang deficiency syndrome, spleen and kidney yang defi- ciency syndrome） in observation group,with the highest rate （82.86%）. The level of TFz in syndrome of kidney - yang deficiency was the lowest as compared with that in syndrome of spleen - yang deficiency, kidney - yang deficien- cy and other syndrome （ P 〈 0.05）. The symptom score of spleen and kidney yang deficiency type was obviously supe- rior to that in the type of spleen - yang deficiency, kidney - yang deficiency and other syndrome （ P 〈 0.05 ）. Conclu- sion The yang deficiency syndrome occupies the first place in low T3 syndrome. The highest occurrence frequency symptom was extreme chilliness, that the spleen and kidney yang deficiency syndrome and spleen yang deficiency svn-drome occupied the highest proportion. The change of serum thyroid hormone level can help to determine the yang deficiency syndrome. The more severe yang deficiency in

关 键 词：功能正常甲状腺病综合征 阳虚 中医证候 

分 类 号：R581[医药卫生—内分泌] R581.904[医药卫生—内科学]