TLR3、TLR9和DC-SIGN在扁平疣患者皮损的表达  

Expression of Toll-like Receptors and C-type Lectin Receptors in Verruca Vulgaris Lesions

作　　者：江中洪[1] 江玉娥[2] 曾茂森[2] 丘波[2] 曾抗[3] 

机构地区：[1]嘉应学院医学院附属医院皮肤科,广东梅州514031 [2]嘉应学院医学院附属医院病理科,广东梅州514031 [3]南方医院皮肤科,广东广州510515

出　　处：《皮肤性病诊疗学杂志》2015年第4期274-277,共4页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：广东省医学科研基金立项课题(编号:B2012376)

摘　　要：目的:探讨扁平疣患者皮损TLR3、TLR9和C型凝集素DC-SIGN的表达及意义。方法:采用免疫组化SP法检测30例扁平疣患者皮损中TLR3、TLR9和DC-SIGN的表达情况,以20例正常人皮肤组织作对照,比较两者TLR和DC-SIGN表达及分布的差异。结果:扁平疣患者皮损TLR3、TLR9和DCSIGN的表达水平均高于正常皮肤组织(χ2值分别为42.18、45.97、45.97,P值均<0.01),且集中分布于基底层和棘层细胞下部,TLR3、TLR9和DC-SIGN的表达均呈正相关性关系(r值分别为0.46、0.43,P值均<0.05)。结论:扁平疣患者皮损TLR3、TLR9和DC-SIGN的表达增强,可能与HPV感染启动机体抗病毒免疫有关。Objective ：To investigate the expression and significance of TLR3, TLR9 and DC- SIGN in verruca vulgaris lesions. Methods：Immunohistochemistry streptavidin peroxidase conju- gated method was performed to detect the expression and distribution of TLR3, TLR9 and DC- SIGN in tissue specimens obtained from 30 patients verruea vulgaris lesions and 20 healthy donors. Results：The expression levels of TLR3, TLR9 and DC-SIGN in verruca vulgaris lesions were sig- nificantly higher than those in normal control tissue （ x2 = 42. 18,45.97,45.97, all P 〈 0. 01 ）, and the cells expressing TLR3, TLR9 and DC-SIGN were mainly located in the basal and spinous layer in verruca vulgaris lesions. A positive correlation was found between the expression of TLR3, TLR9 and DC-SIGN in verruca vulgaris lesions （ r = 0. 46,0.43, both P 〈 0. 05 ）. Conclusion ： The over-expression of TLR3, TLR9 and DC-SIGN in verruca vulgaris lesion might be associated with the activation of antiviral immunity initiated by HPV.

关 键 词：扁平疣 TOLL样受体 C型凝集素 DC-SIGN 

分 类 号：R752.52[医药卫生—皮肤病学与性病学]