奥扎格雷钠联合灯盏细辛制剂治疗脑梗死疗效的系统评价  

Sodium Ozagrel Combined with Dengzhan Xixin Preparations in Treatment of Cerebral Infarction

作　　者：曾超[1] 郑芳[1] 汤坚[1] 谭才宏[1] 汪华君[1] 

机构地区：[1]江苏大学附属医院,江苏镇江212001

出　　处：《中国实验方剂学杂志》2015年第16期201-207,共7页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:系统评价奥扎格雷钠联合灯盏细辛制剂治疗脑梗死的疗效和安全性。方法:计算机检索Pub Med,EMbase,Cochrane Library,西文生物医学期刊文献数据库,中国期刊全文数据库,维普数据库,万方数据库,收集奥扎格雷钠联合灯盏细辛制剂治疗脑梗死的临床随机对照实验(RCT)。对纳入的研究进行方法学质量评价,并采用Rev Man 5.3.4统计软件进行Meta分析。结果:共纳入22项RCT,合计2 198例患者。Meta分析结果显示,奥扎格雷钠联合灯盏细辛制剂能够显著提高患者的总有效率[OR=3.76,95%CI(2.84,4.97),P<0.000 01]、显效率[OR=2.07,95%CI(1.71,2.49),P<0.000 01]及改善神经功能缺损评分[MD=-5.08,95%CI(-5.73,-3.53),P<0.000 01],差异均有统计学意义。结论:奥扎格雷钠联合灯盏细心制剂治疗脑梗死疗效显著,未见明显不良反应,但受纳入文献质量限制,其疗效有待于高质量的随机对照实验进一步证实。Objective： To systematically evaluate the efficacy and safety of sodium ozagrel combined with Dengzhan Xixin preparations in treating cerebral infarction（ CI）. Method： Randomized controlled trails（ RCT）about sodium ozagrel combined with Dengzhan Xixin preparations in the treatment of CI were collected by retrieving from Pub Med,EMbase,Cochrane Library,FMJS,CNKI,VIP and Wanfang database. The methodological quality of the included studies was evaluated,and a Meta-analysis was made for them by Rev Man 5. 3. 4 statistical software.Result： A total of 22 RCT were included,involving 2 198 patients. The results of Meta-analysis showed that sodium ozagrel combined with Dengzhan Xixin preparations could significantly improve the total effective rate [OR = 3. 76,95% CI（ 2. 84,4. 97）,P〈0. 000 01],obvious effective rate [OR = 2. 07,95% CI（ 1. 71,2. 49）,P〈0. 000 01]and neurological deficit scores [MD =- 5. 08,95% CI（- 5. 73,- 3. 53）,P〈0. 000 01 ],with statistical significance in their differences. Conclusion： Sodium ozagrel combined with Dengzhan Xixin preparations is efficient in the treatment of CI,with no significant adverse reaction. However,restricted by the low methodological quality of the trials enrolled in the study,its efficacy shall be further confirmed by a high-quality RCT.

关 键 词：奥扎格雷钠 灯盏细心 灯盏花素 灯盏花素注射液 脑梗死 Meta分析 

分 类 号：R287.6[医药卫生—中药学]