铜催化格氏试剂不对称共轭加成研究进展  

Recent Advances in Copper-Catalyzed Asymmetric Conjugate Addition of Grignard Reagents

作　　者：唐凤翔[1] 叶久勇 

机构地区：[1]福州大学化学学院,福州350116

出　　处：《有机化学》2015年第7期1414-1427,共14页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21375019)资助项目~~

摘　　要：铜催化格氏试剂不对称1,4-、1,6-及1,2-共轭加成是构建手性碳的重要方法,其加成产物是许多天然产物以及手性药物合成的关键中间体.对铜催化的格氏试剂不对称1,4-、1,6-及1,2-共轭加成反应进行了较全面的综述,其中涉及的受体种类包括α,β-不饱和酮、不饱和酯、不饱和内酯、不饱和硫酯、不饱和醛和不饱和砜.此外,对不对称1,4-共轭加成反应的机理研究也进行了较详细的介绍.Copper-catalyzed asymmetric 1,4-, 1,6- and 1,2-conjugate addition of Grignard reagents is an important method to build up a carbon chiral center, which exists in the key intermediates of many natural products and chiral drugs. In this paper, the copper-catalyzed asymmetric 1,4-, 1,6- and 1,2-conjugate addition of Grignard reagents to α、β-unsaturated compounds is summarized systematically, and such acceptors as α、β-unsaturated ketones, esters, lactones, aldehydes, thioesters as well as sulfones are involved. In addition, the mechanism of asvmmetric 1.4-conjugate addition is also introduced.

关 键 词：铜催化 格氏试剂 不对称共轭加成 机理 

分 类 号：O621.251[理学—有机化学]