硫酸镁、硝苯地平片联合丹参注射液对子痫前期患者ET-1/NO、TXA_2/PGI_2及血液流变学的影响  

Effect of Magnesium Sulfate,Nifedipine Tablet Combined Salvia Injection on ET-1/NO,TXA_2/PGI_2,and Hemorheology of Preeclampsia Patients

作　　者：郑晓瑛[1] 姚静[1] 朱加美 李梅[1] 邱淑琼 朱兆霞[1] 张明[1] 

机构地区：[1]山东省诸城市妇幼保健院妇产科,山东262200

出　　处：《中国中西医结合杂志》2015年第8期962-965,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：中国疾病预防控制中心妇幼保健中心妇幼保健分子遗传医学研究专项(No.FY-ZX-ZD-0196)

摘　　要：目的观察硫酸镁、硝苯地平片联合丹参注射液对子痫前期患者内皮素-1(endothelin-1,ET-1)/一氧化氮(nitric oxide,NO)、血栓素A_2(thromboxane A_2,TXA_2)/前列环素I_2(prostacyclin I_2,PGI_2)及血液流变学的影响。方法将704例子痫前期患者随机分为治疗组和对照组,每组352例。两组均使用硫酸镁联合硝苯地平片治疗(第1日:硫酸镁注射液5 g缓慢静脉推注+硫酸镁注射液10 g静脉滴注+硝苯地平片30 mg口服;第2、3日:硫酸镁注射液10 g静脉滴注+硝苯地平片30 mg口服),治疗组加用丹参注射液(20 mL/d,静脉滴注,连续3日)。检测两组治疗前后血浆ET-1、NO、TXA_2、PGI_2及血液流变学指标[全血高切黏度(high blood viscosity,HBV),全血低切黏度(low blood viscosity,LBV),血浆黏度(plasma viscosity,PV),红细胞刚性指数(erythrocyte rigidity index,ERI),纤维蛋白原(fibrinogen,FIB)]。结果与本组治疗前比较,两组治疗后血清ET-1、TXA_2、HBV、LBV、PV、ERI、FIB水平降低(P<0.05),NO、PGI_2水平升高(P<0.05)。与对照组同期比较,治疗组治疗后ET-1、TXA_2、HBV、LBV、PV、ERI、FIB水平降低(P<0.05),NO、PGI_2水平升高(P<0.05)。结论硫酸镁、硝苯地平片联合丹参注射液可有效调节子痫前期患者ET-1/NO、TXA_2/PGI_2平衡,并改善血液流变学。Objective To observe the effect of magnesium sulfate, Nifedipine Tablet （NT） combined Salvia Injection （SI） on endothelin-1 （ ET-1 ）, nitric oxide （ NO）, thromboxane A2 （TXA2）, prostacyclin 12 （PGl2）, and hemorheology of preeclampsia patients. Methods Totally 704 preeclampsia patients were randomly assigned to the treatment group and the control group, 352 cases in each group. All patients were treated with magnesium sulfate combined NT （on the first day. slow intravenous injection of magnesium sulfate 5 g ＋ intravenous dripping of magnesium sulfate injection 10 g ＋oral administration of NT30 mg; on the second and third day, intravenous dripping of magnesium sulfate injection 10 g ＋ oral administration of NT30 mg）, while those in the treatment group were dripped with SI additionally at 20 mL per day for 3 consecutive days. Before and after treatment plasma levels of endothelin-1 （ ET-1 ）, nitric oxide （NO）, TXA2, PGl2, and hemorheology indicators E such as high blood viscosity （HBV）, low blood viscosity （LBV）, plasma viscosity （PV）, erythrocyte rigidity index （ERI）, fibrinogen （FIB） ] of two groups were detected. Results Compared with the same group before treatment, serum levels of ET-1, TXA2, HBV, LBV, PV, ERI, and FIB decreased in the two groups after treatment （P 〈0.05）,but levels of NO and PGl2 increased （P 〈0.05）. Compared with the control group in the same period, levels of ET-1, TXA2 , HBV, LBV, PV, ERI, and FIB decreased in the treatment group after treatment （P 〈0.05） ,but levels of NO and PGl2 increased （P 〈0.05）. Conclusion Magnesium sulfate, NT combined SI could effectively regulate the balance of ET-1/NO and TXA2/PGl2, and improve hemorheology of preeclampsia pa-tients.

关 键 词：子痫前期 硫酸镁 硝苯地平片 丹参注射液 血栓素A2/前列腺环素I2 内皮素-1/一氧化氮 血液流变学 

分 类 号：R714.244[医药卫生—妇产科学]