新型苯并二氮卓类化合物的合成  

Synthesis of Novel Benzodiazepine Compounds

作　　者：石富强[1] 董金丽[1] 张龙[1] 

机构地区：[1]长春工业大学化学工程学院,吉林长春130012

出　　处：《合成化学》2015年第8期687-692,共6页Chinese Journal of Synthetic Chemistry

基　　金：吉林省教育厅"十二五"科学技术研究项目(2105第124号)

摘　　要：分别以2-氯-3-硝基吡啶和4,6-二氯-5-硝基嘧啶为起始原料,经取代、还原、Bischler-Napieralski关环和氧化反应合成了新型含酮羰基的吡啶并苯并二氮卓类化合物(6a^6c)和嘧啶并苯并二氮卓类化合物(6d),其结构经1H NMR,13C NMR和ESI-MS表征。并重点考察了氧化反应条件,实验结果表明,合成6a^6c时,用乙腈作溶剂,硅藻土作载体,氧化效果较好;合成6d时,以THF为溶剂、活性炭为载体,效果较好。Novel pyridine benzodiazepine compounds（6a ~ 6c） and pyridimine benzodiazepine com- pound （6d） were synthesized by substitution, reduction, Bischler- Napieralski cyelization and oxida- tion reaction from 2-chloro-3-nitro pyridine and 4,6-dichloro-5-nitro-pyrimidine, respectively. The structures were characterized by 1H NMR, 13C NMR and ESI-MS. The oxidation reaction conditions were investigated. The results showed that for synthesizing 6a ~ 6c, acetonitrile was the solvent and diatomite was the carrier, and for rid, THF was the solvent and activated charcoal was the carrier.

关 键 词：Bischler-Napieralski关环 吡啶并苯并二氮卓 嘧啶并苯并二氮卓 氧化反应 酮羰基 合成 

分 类 号：O621.3[理学—有机化学] O625[理学—化学]