新型庚铂衍生物的合成  

Synthesis of Novel Eptaplatin Derivatives

作　　者：徐伟[1] 王德才[2] 

机构地区：[1]南京理工大学泰州科技学院化工学院,江苏泰州225300 [2]南京工业大学药学院,江苏南京210009

出　　处：《合成化学》2015年第8期711-715,719,共6页Chinese Journal of Synthetic Chemistry

摘　　要：以D-酒石酸与芳香醛为起始原料,经缩合、氨解和还原反应制得中间体(4R,5R)-4,5-双(氨甲基)-1,3-二氧戊环类化合物(5a^5n);5a^5n分别与氯亚铂酸钾经配位反应合成了14个新型庚铂衍生物(6a^6n);6a^6j依次与硝酸银和丙二酸钠反应合成了10个新型庚铂衍生物,收率18.29%~50.91%,其结构经1H NMR,ESI-MS和元素分析表征。The intermediates, （ 4R, 5R ） -4,5-bis （ aminomethyl ） -2-isopropyl-1,3-dioxolane （ 5a ~ Sn）, Were synthesized by condensation, aminolysis and reduction from D-tartaric acid and aromatic aldehydes. Fourteen novel eptaplatin derivatives（6a ~ 6n） were synthesized by coordination reaction of 5a ~ 5n with dipotassium tetraehloroplatinate. Ten novel eptaplatin derivatives with yields of 18.29% -50.91% were obtained by reaction of6a ~6j with AgNO3 and then sodium malonate. The structures were characterized by 1H NMR, ESI-MS and elemental analysis.

关 键 词：D-酒石酸 芳香醛 庚铂 衍生物 合成 

分 类 号：O621.3[理学—有机化学] O627[理学—化学]