真菌生物膜的研究进展  

The research progress of fungal biofilm

作　　者：李宗辉[1] 孔庆涛[1] 桑红[1] 

机构地区：[1]南京大学医学院附属金陵医院(南京军区南京总医院)皮肤科,南京医学硕士研究生210002

出　　处：《医学研究生学报》2015年第8期870-874,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81371782)

摘　　要：近年来,真菌生物膜引起的相关感染已经成为一个重要的临床问题。研究发现多种真菌均能形成生物膜,如白念珠菌、新生隐球菌、红酵母、烟曲霉、厚皮马拉色菌、荚膜组织胞浆菌等。许多慢性持续性感染与真菌生物膜形成有关。真菌生物膜形成过程复杂,包括黏附、繁殖、成熟和扩散等生长阶段,并且这一过程受多个基因调控。文中从常见人类致病真菌生物膜形成对临床的影响,生物膜的结构及形成过程中的分子机制等方面进行综述。In recent years, fungal biofilms related infection have become an increasingly important clinical problem. Many clinically important fungi can form biofilms, including： Candida albicans, Cryptococeus neoformans, Rhodotorula species, Aspergillus fumigatus, Malassezia pachydermatis, Histoplasma capsulatum. Many chronic persistent infections are associated with the fungal bio- film formation. The developmental phases of fungal biofilms are complicated, including adhesion, colonisation, maturation and dispers- al, which are governed by many genes. This review discusses clinical impact of biofilm formation of the common human pathogenic fun- gi, biofilm structure and the molecular mechanisms during the biofilm formation process.

关 键 词：真菌 生物膜 基因 

分 类 号：R379[医药卫生—病原生物学]