2型糖尿病伴非酒精性脂肪肝患者血清nesfatin-1水平的变化  

Changes of serum nesfatin-1 levels in type 2 diabetes patients with nonalcoholic fatty liver

作　　者：卢东晖[1] 张帆[1] 连晓芬[1] 

机构地区：[1]北京大学深圳医院内分泌科,广东深圳518036

出　　处：《重庆医学》2015年第24期3350-3351,3354,共3页Chongqing medicine

基　　金：深圳市科创委科技研发项目(JCYJ20140415162338840)

摘　　要：目的观察2型糖尿病(T2DM)伴或不伴非酒精性脂肪肝(NAFLD)患者血清nesfatin-1水平的变化。方法检测T2DM组(211例,其中T2DM不伴NAFLD组98例,T2DM伴NAFLD组113例)和对照组(NGT)组(75例)的空腹血清nesfatin-1水平,同时测定身高、体质量、血糖(GLU)、血脂谱、胰岛素水平(INS)、糖化血红蛋白(HbA1c)、谷丙转氨酶水平(ALT),计算BMI、胰岛素抵抗指数(HOMA-IR)。结果 T2DM组血清nesfatin-1水平均明显高于NGT组(P<0.05),T2DM组中T2DM伴NAFLD亚组血清nesfatin-1水平高于T2DM不伴NAFLD组(P<0.05)。T2DM组nesfatin-1与病程中度相关(r=-0.477,P<0.05)T2DM组中脂肪肝的发生与BMI、TG、nesfatin-1有关(P<0.05)。结论 nesfatin-1可能参与T2DM及NAFLD的发生。Objective To investigate serum nesfatin-1 levels in type 2 diabetes （T2DM） patients with or without nonalcohol- ic fatty liver（NAFLD）. Methods The hight,weight,serum GLU,lipid profiles,INS,HbAlc,ALT,nesfatin-1 levels were measured in 211 T2DM patients[98 without NAFLD（TD2M without NAFLD group） and 113 with NAFLD（TD2M with NAFLD group）] and 75 normal subjects（NGT group）. BMI~ HOMA-IR were also calculated. Results The serum nesfatin-1 level was significantly higher in T2DM group than those in NGT group（P^0.05） ,and T2DM with NAFLD group had higher nesfatin-1 level than T2DM without NAFLD group （P 〈 0. 05）. There was a close relation between nefastin-1 of T2DM group and course of disease （r=-0. 447,P〈0.05）. NAFLD existed a significant correlation with BMI,TG and nesfatin-l（P〈0.05）. Conclusion nesfatin-1 may partially contribute to the pathogenesis of T2DM and NAFLD.

关 键 词：糖尿病 2型 人体质量指数 非酒精性脂肪肝 NESFATIN-1 

分 类 号：R587.1[医药卫生—内分泌]