改良过夜与短时受精对体外受精及临床妊娠结局的影响  

Effects of improved overnight fertilization and short time fertilization on in vitro fertilization and clinical pregnancy outcome

作　　者：张纯[1] 张帆[2] 郑洁[1] 何联[1] 

机构地区：[1]湖北省妇幼保健院生殖医学中心,湖北武汉430070 [2]华中科技大学同济医学院附属同济医院产科

出　　处：《中国妇幼保健》2015年第24期4167-4169,共3页Maternal and Child Health Care of China

基　　金：湖北省妇幼保健院课题〔220927006;220933006〕

摘　　要：目的探讨改良过夜受精与短时受精对体外受精（IVF）及临床妊娠结局的影响。方法回顾2012年8月～2014年5月于湖北省妇幼保健院生殖医学中心接受改良过夜受精及短时受精的IVF患者。改良过夜受精IVF组共132周期,短时受精IVF组共131周期,比较两组患者的基本情况、受精、胚胎发育及临床妊娠情况。结果改良过夜受精IVF组与短时受精IVF组2 PN率、0 PN率、1 PN率、多PN率及受精率比较差异均有统计学意义（P〈0.05）;两组卵裂率、胚胎利用率及临床妊娠率比较,差异无统计学意义（P〉0.05）。结论改良过夜受精虽不能提高临床妊娠率,但可能通过提高2 PN率及受精率在一定程度上提高卵子使用效率。Objective To explore the effects of improved overnight fertilization and short time fertilization on in vitro fertilization （IVF） and clinical pregnancy outcome. Methods The patients receiving improved overnight fertilization （ 232 cycles） and short time ferti- lization （ 231 cycles） in Reproductive Center of the hospital from August 2012 to May 2014 were analyzed retrospectively; the general condi- tions, fertilization, embryo development, and clinical pregnancy rates in the two groups were compared. Results There were statistically significant differences in 2 PN rate, 0 PN rate, 1 PN rate, multi-PN rate, and fertilization rate between the two groups （P〈0. 05） ; there was no statistically significant differences in cleavage rate, embryo utilization rate, and clinical pregnancy rate between the two groups （P〉 0. 05） . Conclusion Improved overnight fertilization can＇t improve clinical pregnancy rate, but it may improve oocyte utilization rate to a certain extent by improving 2 PN rate and fertilization rate.

关 键 词：体外受精 过夜受精 短时受精 胚胎质量 

分 类 号：R321.2[医药卫生—人体解剖和组织胚胎学]