新疆锡伯族、蒙古族高血压患者血清CyPA水平变化及其临床意义  

Correlation of serum cyclophilin A level with occurance of essential hypertension in Xinjiang Xibo and Mongolia populations and its clinical significance

作　　者：王忠[1] 郑丽华[2] 巴音巴特 徐晓红 王春勇[4] 任宏强[1] 赵若飞[2] 

机构地区：[1]新疆石河子大学医学院第一附属医院心内二科,832000 [2]新疆石河子大学医学院 [3]新疆博尔塔拉蒙古自治州人民医院心内科 [4]新疆察布查尔锡伯自治县人民医院

出　　处：《天津医药》2015年第8期879-882,共4页Tianjin Medical Journal

基　　金：新疆兵团医药卫生专项基金资助项目(2012AB014)

摘　　要：目的观察新疆锡伯族、蒙古族原发性高血压(EH)患者血清亲环素A(Cy PA)水平并探讨其临床意义。方法选取锡伯族EH患者76例和健康对照者62例,蒙古族EH患者66例和健康对照者57例。采用酶联免疫吸附法(ELISA)测定血清Cy PA,检测各组的年龄、体质量指数(BMI)、腰围、腰臀比、血压等各项指标,并分析血清Cy PA与各指标的相关性。结果新疆锡伯族、蒙古族EH组血清Cy PA水平均显著高于健康对照组(P<0.05);蒙古族EH组血清Cy PA水平显著高于锡伯族EH组(P<0.05);高血压患者血清Cy PA水平与血压呈正相关(P<0.05)。结论新疆锡伯族、蒙古族EH患者血清Cy PA明显升高,并与血压存在一定的相关性。血清Cy PA升高是新疆锡伯族、蒙古族EH的危险因素。Objective To investigate the correlation of cyclophilin A （CyPA） level in patients with essential hypertension（EH）in Xinjiang Xibo and Mongolia populations and to investigate its clinical significance. Methods EH patients （n=76） and healthy control subjects （n=62） were selected from Xinjiang Xibo populations. On the other hand, EH patients （n=66）and healthy control subjects （n=57） were selected from Xinjiang Mongolia populations. Serum cyclophilin A was measured using enzyme-linked immunosorbent assay（ELISA）. Parameters such as age, body mass index（BMI）, waist, waist hip ratio, blood pressure were measured in each group. The correlation of cyclophilin A with each parameter was analyzed. Results The levels of serum cyclophilin A in EH patients in Xinjiang Xibo and Xinjiang Mongolia populations were significantly higher than those in their corresponding healthy control groups（P〈0.05）. Serum cyclophilin A in patients with essential hypertension（EH）in Xinjiang Mongolia population was signifantly higher than that in EH patients from Xinjiang Xibo population （P〈0.05）. There was a positive correlation between serum cyclophilin A level and occurance of EH in both Xinjiang Xibo and Xinjiang Mongolia populations. Conclusion The serum cyclophilin A is significant higher in EH patients in both Xinjiang Xibo and Xinjiang Mongolia populations so it is positively correlated with occurance of EH （P〈0.05）. Cyclophilin A level is a risk factor of essential hypertension in both Xinjiang Xibo and Xinjiang Mongolia populations.

关 键 词：高血压 血压 锡伯族 蒙古族 

分 类 号：R544.1[医药卫生—心血管疾病]