免疫接种次数对阻断高乙肝病毒载量母婴传播的影响  

Effect of vaccination number on blocking spread of HBV from mother with high load HBV to infants

作　　者：王根菊[1] 王翠敏[1] 丁祎[1] 阚乃颖[1] 江红秀[1] 石金美 韩国荣[1] 

机构地区：[1]东南大学附属南京第二医院妇产科,江苏省210003

出　　处：《江苏医药》2015年第15期1795-1797,共3页Jiangsu Medical Journal

基　　金：江苏省自然科学基金(BK2010026);江苏省卫生厅预防医学基金(Y2012074);南京市卫生局医学基金(YKK12119)

摘　　要：目的观察乙型肝炎(乙肝)疫苗(HBVac)接种次数对阻断高HBV载量母婴传播效果的影响。方法抽取30例HBeAg阳性孕妇足月分娩婴儿(A组,孕妇临产时HBV DNA均>1×106copies/ml)和27例同期条件匹配生产的婴儿(B组)血液标本检查HBVM和HBV DNA定量,予出生时和15d肌肉注射乙肝免疫球蛋白(HBIG)200IU各1针;HBVac 20μg肌肉注射:A组婴儿按0、1、2、6个月方案;B组婴儿按0、1、6个月方案注射。结果随访至7个月龄。免疫程序结束后,A、B两组婴儿抗-HBs滴度、HBeAg值下降速度相仿(P>0.05),但B组有2例婴儿抗-HBs阴性,7例抗-HBs低于100mIU/ml。A、B两组婴儿的ALT和AST差异均无统计学意义(P>0.05)。结论 HBeAg阳性高病毒载量孕妇所生婴儿出生后应用HBIG及HBVac可以获得较好的免疫保护,增加HBVac注射次数可提高婴儿抗-HBs滴度。Objective To observe the effect of vaccination number on blocking the spread of HBV from mother with high load of HBV to the infants. Methods Blood samples were taken for the determinations of HBVM and HBV DNA in 30 mothers with high load of of HBV （HBV DNA〉IX 106 copies/ml） and their infants,who were vaccinated of HBVac 20 μg with a scheme of 0,1,2 and 6 months（group A） and in 27 infants（group B）, who had the matched mothers as in group A and vaccinated of HBVac 20μg with a scheme of 0,1 and 6 months. Hepatitis B immune globulin（HBIG） 200 IU was injected intramuscularly at birth and 15 days of age in both groups. Results The infants were followed up for 7 months. At the end of vaccination, the anti-HBs titer, decrease of HBeAg of both groups were similar（P〉0. 05）. The anti-HBs negative was seen in 2 cases and 7 infants had anti-HBs titer less than 100 mIU/ml in group ]3. There were no significant differences in ALT and AST in both groups （P〉0. 05）. Conclusion The vaccination with HBIG and HBVac can produce better immune protection on the infants, who have the mothers with high load of HBV DNA. An increase of number for HBVac injection may increase anti-HBs titer.

关 键 词：乙型肝炎病毒 乙肝疫苗 

分 类 号：R714[医药卫生—妇产科学]