抑郁症患者对正性情绪图片增强和减弱认知重评的fMRI研究  

Neural Substrates of Abnormal Positive Emotion Regulation in Depressed Patients

作　　者：王晓霞[1] 蒋成刚[2] 李静[3] 冯正直[4] 

机构地区：[1]第三军医大学心理学院基础心理学教研室,重庆400038 [2]第三军医大学大坪医院野战外科研究所睡眠心理中心,重庆400042 [3]第三军医大学西南医院影像科,重庆400038 [4]第三军医大学心理学院行为医学教研室,重庆400038

出　　处：《中国临床心理学杂志》2015年第4期615-620,575,共7页Chinese Journal of Clinical Psychology

基　　金：国家自然科学基金项目(30970898);军队医药卫生课题(BWS14J029)

摘　　要：目的:通过认知重评任务考察抑郁症正性情绪调节异常特点及其脑机制。方法:收集抑郁症组14名被试和对照组16名被试,并匹配其性别、年龄和文化程度,利用认知重评任务考察抑郁症正性情绪调节异常的脑功能联结特点。结果:在行为学方面,抑郁症患者能够使用认知重评策略增强和减弱正性情绪。功能磁共振成像结果显示,上调正性情绪时,抑郁症患者左侧眶额叶、右侧颞中回/颞极等区域激活低于对照组,双侧梭状回、左侧舌回、右侧小脑等区域激活高于对照组;下调正性情绪时,抑郁症患者右侧颞中回/颞极激活低于对照组。结论:抑郁症患者难以调用所需要认知资源增强和减弱正性情绪,认知控制能力下降,并表现出情绪调节相关区域(眶额叶、颞叶)活动异常。Objective： To examine the neural substrates of abnormal positive emotion regulation using cognitive reap- praisal paradigm. Methods： 14 patients and 16 controls matched with gender, age and education were recruited, and under- went reappraisal task during fMRI scanning in a 3.0T scanner. Imaging data were preprocessed and analyzed with SPM 8 software. Results： When up regulating positive emotion, depressed patients showed reduced activity in the orbito-frontal cortex, right temporal gyrus/temporal pole and increased activity in the bilateral fusiform gyrus, left lingual gyrus and right cerebellum. In addition, depressed patients failed to recruit the right middle temporal gyrus/temporal pole to down-regulate positive emotion. Conclusion： Depressed patients have deficits in cognitive control function, which may lead to their inabil- ity to recruit cognitive control resources to enhance and reduce positive emotion. This cognitive deficit may be underlied by abnormal functions in the orbital-frontal gyrus and temporal gyrus associated with emotion regulation.

关 键 词：抑郁症 正性情绪调节 认知重评 眶额皮层 颞叶 

分 类 号：R395.1[哲学宗教—心理学]