Fabrication of multiwalled carbon nanotube-surfactant modi fi ed sensor for the direct determination of toxic drug 4-aminoantipyrine  

作　　者：Jayant I.Gowda Arunkumar T.Buddanavar Sharanappa T.Nandibewoor 

机构地区：[1]P.G. Department of Studies in Chemistry, Karnatak University

出　　处：《Journal of Pharmaceutical Analysis》2015年第4期231-238,共8页药物分析学报（英文版）

摘　　要：A multi-walled carbon nanotube （MWCNT）-cetyltrimethylammonium bromide （CRAB） surfactant com- posite modified glassy carbon electrode （GCE） was developed as a novel system for the determination of 4-aminoantipyrine（AAP）. The oxidation process was irreversible over the pH range studied and exhibited a diffusion controlled behavior. All experimental parameters were optimized. The combination of MWCNT-CRAB endows the biosensor with large surface area, good biological compatibility, electricity and stability, high selectivity and sensitivity. MWCNT-CTAB/GCE electrode gave a linear response for AAP from 5.0 x 10-9 to 4.0 x 10-8 M with a detection limit of 1.63 x 10 lo M. The modified electrode showed good selectivity against interfering species and also exhibited good reproducibility. The present elec- trochemical sensor based on the MWCNT-CFAB/GCE electrode was applied to the determination of AAP in real samples.A multi-walled carbon nanotube （MWCNT）-cetyltrimethylammonium bromide （CRAB） surfactant com- posite modified glassy carbon electrode （GCE） was developed as a novel system for the determination of 4-aminoantipyrine（AAP）. The oxidation process was irreversible over the pH range studied and exhibited a diffusion controlled behavior. All experimental parameters were optimized. The combination of MWCNT-CRAB endows the biosensor with large surface area, good biological compatibility, electricity and stability, high selectivity and sensitivity. MWCNT-CTAB/GCE electrode gave a linear response for AAP from 5.0 x 10-9 to 4.0 x 10-8 M with a detection limit of 1.63 x 10 lo M. The modified electrode showed good selectivity against interfering species and also exhibited good reproducibility. The present elec- trochemical sensor based on the MWCNT-CFAB/GCE electrode was applied to the determination of AAP in real samples.

关 键 词：VoltammetryModified electrodeDiffusion controlled4-aminoantipyrinePharmacokinetic study 

分 类 号：R927.2[医药卫生—药学]