封闭抗体阴性的早期流产患者使用被动免疫治疗的效果观察  

Clinical observation of passive immunotherapy for the early abortion patients with negative blocking antibodies

作　　者：王丽娜[1] 陈映婷[1] 

机构地区：[1]广东省珠海市妇幼保健院产科,广东珠海519000

出　　处：《中国计划生育和妇产科》2015年第8期74-75,78,共3页Chinese Journal of Family Planning & Gynecotokology

基　　金：广东省珠海市医疗卫生项目(项目编号:02196711140710018)

摘　　要：目的 观察封闭抗体阴性的早期流产患者在孕激素等常规治疗的基础上加用被动免疫治疗的效果。方法 选取2012~2014年在广东省珠海市妇幼保健院80例确诊封闭抗体阴性的早孕保胎患者资料,将采用孕激素、人绒毛膜促性腺激素等常规保胎治疗患者40例纳入对照组,另40例在对照组基础上采用丙种免疫球蛋白治疗患者纳入观察组,比较两组患者的妊娠成功率。结果 观察组继续妊娠至12周成功率为75.0%（30/40）.对照组继续妊娠至12周成功率为52.5%（21/40）,两组比较差异有统计学意义（P〈0.05）。结论 对于封闭抗体阴性的早期自然流产患者积极采用被动免疫治疗联合常规激素保胎治疗可提高妊娠成功率。Objective To study the effect of passive immunotherapy combined with conventional tocolytic therapy for the early abortion patients with negative blocking antibodies. Methods Clinical data of 80 early pregnancy tocolysis patients with negative blocking antibodies in Maternal and Child Health Hospital of Zhuhai City from 2012 to 2014 were selected,all cases were divided into observation group and control group with 40 cases in each group. The conventional tocolytie therapy such as progesterone and HCG injection were used in control group, on the basis of control group, gamma immunoglobulin were used in observation group. The pregnancy success rate of two groups were compared. Results The success rate of pregnancy to 12 weeks of observation group and control group were 75.0 % （30/40）and 52. 5 % （21/40） respectively,the difference was significant between the two groups （P 〈 0.05）. Conclusion The combination of passive immunotherapy and hormonotherapy for the early spontaneous abortion patients with negative blocking antibodies can improve pregnancy success rate.

关 键 词：早期自然流产 封闭抗体 丙种免疫球蛋白 孕激素 

分 类 号：R714.21[医药卫生—妇产科学]