抗疟中草药筛选及其有效部位研究  

Screen The Antimalarial Chinese Medicinal Herb and Research its Effective Parts

作　　者：周泽琴[1] 张雄飞[1] 胡梁及 蔡兴[1] 钟娜娜[1] 朱盛山[1] 

机构地区：[1]广东药学院中药开发研究所,广东广州510006

出　　处：《亚太传统医药》2015年第16期6-8,共3页Asia-Pacific Traditional Medicine

摘　　要：目的:为寻找新的有效抗疟药物提供实验依据。方法:建立伯氏疟原虫鼠疟实验模型,比较常山复方、金牛草、山豆根、鹅不食草、常山、仙鹤草、青蒿等药物的50%醇提取物抗疟活性,比较抗疟活性最强醇提取物中不同萃取部位对疟原虫的抑制效果。结果:常山复方的50%醇提取物疟原虫抑制率为83.46%,高于青蒿药材的67.33%,抗疟效果比较差异具有统计学意义(P<0.05);常山复方的50%醇提取物乙酸乙酯萃取部位对疟原虫的抑制率达93.78%,与青蒿素的95.92%接近。结论:常山复方乙酸乙酯萃取物具有显著的抗疟活性,可作为抗击疟疾的候选药物。Objective ： For finding new, effective antimalarial medicines and provide experimental bases. Methods ： The experimen- tal models were established by mice infected with Plasmodium berghei. Compare the antimalarial activity of 50 % ethanol extracts of compound Dichroa febrifuga Lour, Polygala arvensis Willd, Radix Sophorae Subprostratae, Centipeda minima, Dichroa febrifuga Lour, Agrimonia pilosa,Artemisia apiacea. Picked out the highest reactive ethanol extracts ：compound Dichroa febrifuga Lour. Then, compare the suppression effect on plasmodium from its different extractive fractions. Results： The plasmodium inhibition of 50% ethanol extracts of compound Dichroa febrifuga Lour and Artemisia apiacea were 83.46 % and 67.33%, respectively , which had statistical significance （P〈 0. 05） The plasmodium inhihition of ethyl acetate extracts of compound Dichroa febrifuga Lour was 93.78% and artemisinin was 95.92 %. Conclusion. The ethyl acetate extracts of compound Dichroa febrifuga Lour has significant antimalarial activity,which could be the new candidate antimalarial medicines as a priority.

关 键 词：抗疟 常山复方 伯氏疟原虫 抑制率 

分 类 号：R289[医药卫生—方剂学]