霍乱毒素B亚单位作为免疫佐剂的研究进展  

Recent advances in the development of cholera toxin B subunit as immune adjuvant

作　　者：贾岚[1] 洪艳[1] 

机构地区：[1]浙江省医学科学院生物工程研究所,杭州310013

出　　处：《国际流行病学传染病学杂志》2015年第4期266-268,共3页International Journal of Epidemiology and Infectious Disease

基　　金：浙江省自然科学基金（LY12H19009）;浙江省科技厅计划项目（2011C23002、2011F20015）

摘　　要：霍乱肠毒素（CT）是霍乱弧菌重要的毒力因子，内含A和B两个亚单位。A亚单位（CTA）为毒性亚基，B亚单位（CTB）不具毒性。CTB因其独特的生理功能已成为重要的佐剂之一，近年来备受各国学者重视。深入探究CTB的免疫调节机制有助于更好地设计疫苗并优化其效果，此文将对CTB作为免疫佐剂在疫苗研究中的进展进行综述。Cholera toxin （CT） is the important virulence factor of Vibrio cholerae which is composed of A and B subunits. Cholera toxin A subunit （CTA） is toxic, while B subunit （CTB） is nontoxic and has become one of the important adjuvants and been paid much attention by scholars in recent yearn because of its unique physio- logical function. Better understanding of immunomodulatory mechanism of CTB would be helpful to develop and improve novel vaccines. This paper discusses the latest progress of CTB as immune adjuvant in vaccine research.

关 键 词：霍乱毒素 佐剂 疫苗 

分 类 号：R392[医药卫生—免疫学]