3.0 T DCE-MRI定量分析在前列腺癌与增生鉴别诊断中的应用价值  

Quantitative diagnostic value of 3.0 T dynamic contrastenhanced MRI in different diagnosis of prostate cancer and hyperplasia

作　　者：徐嬿[1] 冷晓明[1] 郑芸[1] 赵曼[1] 曾道辉[1] 韩晓蕊[1] 冯欣[1] 王晓春[1] 

机构地区：[1]广州中医药大学第一附属医院影像科,广州510405

出　　处：《磁共振成像》2015年第8期608-612,共5页Chinese Journal of Magnetic Resonance Imaging

摘　　要：目的探讨3.0 T磁共振动态增强扫描(dynamic contrast-enhanced MRI,DCE-MRI)定量分析对前列腺癌和前列腺增生鉴别诊断的应用价值,并评价定量指标Ktrans、Kep、Ve与Gleason评分的相关性。材料与方法回顾性分析43例经病理证实的前列腺疾病患者的影像资料,其中前列腺癌(prostate cancer,PC)27例,前列腺增生(benign prostatic hyperplasia,BPH)16例,均行常规MRI和DCE-MRI检查,在定量分析软件上测量病灶的容积转运常数(Ktrans)、速率常数(Kep)、血管外细胞外容积分数(Ve)值,比较三者在前列腺癌组和增生组中的差异,并评价前列腺癌组Ktrans、Kep、Ve值与Gleason评分的相关性。结果前列腺癌组织的Kt r a n s、Ke p、Ve分别为(0.312±0.085)min-1、(0.818±0.098)min-1和(0.379±0.031),前列腺增生组织的Ktrans、Kep、Ve分别为(0.213±0.046)min-1、(0.537±0.076)min-1和(0.324±0.034),前列腺癌组织的Kt r a n s、Ke p、Ve明显高于增生组织,差异有统计学差异(P<0.001);前列腺癌区的Ktrans、Kep、Ve值与Gleason评分无明显相关性。结论 DCEM R I定量分析在前列腺癌的诊断中具有较高价值,有利于前列腺良恶性病变的鉴别诊断。前列腺癌区的Kt r a n s、Ke p、Ve值与Gleason评分无明显相关性。Objective：To explore the diagnostic value of quantitative analysis parameters of DCE-MRI in prostate cancer diagnosis, and to evaluate the correlation between Ktrans, Kep and Ve and Gleason scores. Materials and Methods：Forty-three prostate diseases patients pathologically proved underwent conventional MRI and DCE-MRI examinations, including 27 patients with prostate cancer and 16 with prostate hyperplasia. The variations of the value of Ktrans, Kep and Ve between the prostate cancer and hyperplastic tissues were measured and compared, and the correlations between Ktrans, Kep and Ve and Gleason scores were studied.Results：The Ktrans, Kep and Ve values of cancerous area were （0.312±0.085） min-1, （0.818±0.098） min-1 and （0.379±0.031）, while, for hyperplastic area were （0.213±0.046） min-1, （0.537±0.076） min-1 and （0.324±0.034）. The values of Ktrans, Kep, Ve were signiifcantly higher in prostate cancer than in hyperplastic tissues; and Ktrans, Kep, Ve values were not relevant with Gleason score.Conclusion：DCE-MRI quantitative analysis plays a signiifcant role in prostate cancer diagnosis, and may help in differential diagnosis of prostate tumors. Ktrans, Kep and Ve values were not relevant with Gleason score.

关 键 词：前列腺肿瘤 前列腺增生 动态增强 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.25[医药卫生—诊断学]