血脂异常血瘀证患者血液流动性和流变性观察  

Observation of the Blood Flow and Rheology in Patients with Blood Stasis Syndrome and Dyslipidemia

作　　者：赵浩[1,2] 刘剑刚[1] 雷燕[3] 

机构地区：[1]中国中医科学院西苑医院,中国中医科学院心血管病研究所,北京100091 [2]中国中医科学院广安门医院南区,北京102600 [3]中国中医科学院医学实验中心,北京100700

出　　处：《微循环学杂志》2015年第3期23-26,F0004,共5页Chinese Journal of Microcirculation

基　　金：中日合作血液流变学可视化基金项目(XYW01-20100526)

摘　　要：目的:应用计算机血液流变学可视化技术(MC-FAN)观察血脂异常患者血液流动性,探讨血脂异常血瘀证患者血液流动性与中医血瘀证之间的关系。方法:98例血脂异常患者,按照中医辩证分型分为血瘀证组(n=50)和非血瘀证组(n=48),另设健康人群为对照组(n=29)。平行测定各组血脂指标总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、极低密度脂蛋白-胆固醇(VLDL-C)以及血液流变学指标全血表观粘度(BV)、血浆粘度(PV)、红细胞压积(HCT)、红细胞聚集指数(EAI)、红细胞变形指数(EDI)、血浆纤维蛋白原(Fib)、血小板聚集率(PTGT)和血小板黏附率(PAdT),并利用MC-FAN观察血液流动时间(TT)。结果:与对照组比较,血瘀证组和非血瘀证组患者各血脂指标水平均显著升高(P<0.01),但两患者组间差异无统计学意义(P>0.05)。血瘀证患者(25μl、50μl、75μl、100μl)血液的TT分别为21.48±7.19s,52.92±18.72s,94.11±33.00s和164.60±65.20s,较非血瘀证组患者(17.70±4.14s、40.84±14.88s、69.90±27.76s、110.06±47.24s)均显著延长(P<0.01)。三组间血液流变学各指标差异均无统计学意义(P>0.05)。结论:血脂异常血瘀证患者的血液流动时间显著延长。Objective： To explore the relationship between theology and blood stasis of traditional Chinese medicine （TCM） of hyperlipidemia with the MC-FAN, Method A total of 127 cases were enrolled,and tested all the patients＇ lipid, MC-FAN TT and hemorheology indexes. The 98 hyperlipldemia patients were divided into the Blood stasis group and non-blood stasis group with the rule of traditional Chinese medicine, and the other 29 normal lipid eases were in the controlled group. Results： Compared with healthy people, the blood lipid indicators rised in the blood stasis group and the non-blood stasis group, The MC-FAN TT （25μl TT is 21.48±7.19s,50μl TT is 52.92± 18.72s,75μl TT is 94.11±33.00s and 100μl TT is 164.60±65. 20s, P〈0.01） were extended,compared with non-blood stasis group. There were no significant differences between the 3 groups in rheology. Conclusion： For the patients of hyperlipidemia in blood stasis group, the MC-FAN TT is extended.

关 键 词：血脂异常 血瘀证 血液流动时间 计算机可视化技术 

分 类 号：R285.5[医药卫生—中药学] R364.1[医药卫生—中医学]