妊娠期糖尿病患者糖化血红蛋白水平与凝血功能分析  

Analysis of HbA1c and Blood Coagulation Function in GDM Women

作　　者：石祖亮[1] 杨林[1] 

机构地区：[1]湖北省妇幼保健院,武汉430070

出　　处：《微循环学杂志》2015年第3期62-64,共3页Chinese Journal of Microcirculation

摘　　要：目的:检测分析妊娠期糖尿病(GDM)患者临产时糖化血红蛋白(HbA1c)水平和凝血功能变化及其相关性。方法:659例GDM患者,采用高效液相色谱法检测HbA1c,依据其水平分为HbA1c<6.5%组(n=584)和HbA1c≥6.5%组(n=75),另选同期正常孕妇作为对照组(n=120)。采用Clauss凝固法平行检测三组血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和纤维蛋白原(Fib)浓度。统计学分析组间差异及凝血指标与HbA1c的相关性。结果:HbA1c≥6.5%组PT时间短于对照组和HbA1c<6.5%组,Fib水平高于对照组和HbA1c<6.5%组,差异均有统计学意义(P<0.05)。相关性分析显示Fib与HbA1c呈正相关关系(r=0.192,P<0.01)。结论:GDM患者可能存在血栓前状态。Objective： To analysis the changes of glycosylated hemoglobin（HbAlc） and coagulation function in patients with gestational diabetes mellitus （GDM）, and to investigate the correlation between HbAlc and the index in labor. Method： High performance liquid chromatography （HPLC） was used to measure HbAlc of pregnant women （n=659 cases） with GDM, then according to HbAlc was less than 6.5% （n=584 cases） and HbAlc was more than or equal to 6.5% （n=75 cases）,patients were divided into two groups, the normal pregnant women as control group （n= 120 cases）. Clauss coagulation method was used to measure prothrombin time （PT）, the activated partial thromboplastin time （APTT）, fibrinogen （Fib） concentration in parallel. Results： In HbAlc≥ 6. 5% group, PT was shorter and the Fib concentration was higher when compared with the control group and HbAlc〈6. 5% group, the difference was statistically significant （P〈0.05）. Correlation analysis showed that the level of Fib were positively correlated with the Index of HbAlc（r=0. 192, P〈0.01）. Conclusion： GDM women probably have the state of significant hypercoagulation.

关 键 词：妊娠期糖尿病 糖化血红蛋白 凝血功能 

分 类 号：R714.256[医药卫生—妇产科学]