复方茵陈汤治疗急性胆道感染临床疗效及相关机理探讨  

Therapeutic Evaluation and Mechanical Exploration on Treatment of Acute Infection of Biliary Tract with Fufang-Yinchen Decoction

作　　者：杨静[1] 赵滨[1] 曹峰[1] 

机构地区：[1]上海市第七人民医院普外科,上海200137

出　　处：《中国中西医结合外科杂志》2015年第4期339-342,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：上海市第七人民医院人才培养计划资助项目(XX2012-011)

摘　　要：目的：研究复方茵陈汤结合西医治疗急性胆道感染的效果及对炎症反应的调节作用。方法：采用双盲随机对照试验,收集急性胆道感染病例60例,随机分成对照组和观察组各30例;对照组接受常规西医治疗,观察组在常规西医治疗基础上加服复方茵陈汤。结果：观察组退热、腹部疼痛及体征缓解的时间均短于对照组（P〈0.01）;治疗3 d、5 d后,观察组血白细胞计数（WBC）、中性粒细胞百分比（N）、C反应蛋白（CRP）、降钙素原（PCT）,白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、髓系细胞触发受体1（TREM1）水平均低于对照组（P〈0.01～0.05）;且观察组治疗3 d后WBC、N、CRP、PTC、IL-6、TNF-α、TREM1水平明显低于治疗前（P〈0.01）,而同期对照组数据仅IL-6水平明显低于治疗前（P〈0.05）;观察组总有效率93.33%,对照组73.33%（P〈0.05）。结论：与常规西医治疗相比,复方茵陈汤结合西医治疗能更快缓解症状体征,并且更快更有效地控制感染,减轻炎症反应。Objective To study the effect of Fufang-Yinchen decoction combined with western medicine in treatment of acute infection of the biliary tract,and of the intervention of inflammatory response. Methods Double-blind, randomized, parallel controlled clinical trial was made in 60 patients with acute infection of biliary tract. All were randomly divided into control group and observation group, 30 cases in each. The control group received conventional western medicine treatment, the observation group： in addition to the treatment of Western medicine, received compound oriental wormwood decoction. Results Fever, abdominal pain and abdominal signs relief time, in the observation group were shorter than those in the control group, with statistically significant difference （P〈0.01）. For 3 days, 5 days later, WBC, N, CRP, PCT, IL-6, TNF- α, TREM1 levels, in the observation group were lower than those in the control group, with statistically significant difference （P〈0.01～0.05）. For 3 days later,WBC, N, CRP, IL-6, TNF- α, TREM1 level, were lower than those before treatment in the observation group with statistically significant difference （P〈0.01）, however, only the IL-6 was lower than before treatment in the control group（P〈0.05）. The total efficiency of the observation group was 93.33%higher than that of the control group 73.33%, with statistically significant difference （P〈0.05）. Conclusion Compared with the conventional western medicine treatment, Fufang-Yinchen decoction combined with western medicine controls infection faster and more effective, moreover it reduces systemic inflammatory response.

关 键 词：急性胆道感染 复方茵陈汤 炎症因子 

分 类 号：R657.41[医药卫生—外科学]