最小临床重要差值在COPD生存质量测评工具中的应用  

Application of Minimal Clinically Important Difference in Quality of Life Assessment Tools for COPD Patients

作　　者：孙辉[1,2] 谢洋[2,3] 李建生[1,2] 

机构地区：[1]河南中医学院老年医学研究所,河南省郑州市450046 [2]呼吸疾病诊疗与新药研发河南省协同创新中心 [3]河南中医学院第一附属医院肺病科

出　　处：《中国全科医学》2015年第23期2826-2829,共4页Chinese General Practice

基　　金：国家科技支撑计划课题(2014BAI10B00);国家自然科学基金面上项目(81473648);国家自然科学基金青年基金项目(30772797)

摘　　要：生存质量量表/问卷等测评工具日益被应用于COPD患者的临床疗效评价,而对测评工具评分的解释和判定尤为重要。根据统计学差异去判定疗效已显示出其局限性,采用最小临床重要差值(MCID)判断测评工具的分值改变是否具有临床重要意义逐渐受到重视。本文介绍了MCID的常用测量方法,包括效标法、分布法、文献分析法和专家意见法,重点论述各方法在不同测评工具中的具体应用,探讨测量方法、患者人口统计学特征和基线资料、患者能力及研究周期等对MCID评估的影响。Assessment tools , including quality of life scale or questionnaire , are increasingly being used in COPD clinical evaluation , thus it′s very important to interpret and judge the value of these tools .To determine efficacy according to statistical differences has shown its limitation .Minimal clinically important difference （ MCID） is obtaining increasing attention , for it determines whether the change of evaluation tool scores holds clinically important value .In this article, we introduced the common MCID measurement methods , including anchor -based methods , distribution based methods , document analysis and expert perception , and focused on the methods in the application of various assessment tools .We came to the collusion that MCID assessment may be influenced by assessment methods , demographic characteristics of patients , baseline data , patients′ability and research cycle .

关 键 词：肺疾病  慢性阻塞性 最小临床重要差值 生存质量 

分 类 号：R563.9[医药卫生—呼吸系统]