2004-2013年河南省脊髓灰质炎疫苗相关麻痹型病例分析  

Case analysis of vaccine-associated paralytic poliomyelitis in Henan between 2004 and 2013

作　　者：张肖肖[1] 王长双[1] 肖占沛[1] 王燕[1] 路明霞[1] 马雅婷[1] 张延炀[1] 

机构地区：[1]河南省疾病预防控制中心免疫规划所,河南郑州450016

出　　处：《现代预防医学》2015年第16期3033-3035,共3页Modern Preventive Medicine

摘　　要：目的了解河南省疫苗相关麻痹型脊髓灰质炎（Vaccine-Associated Paralytic Poliomyelitis,VAPP）病例发生情况,为其防控策略制定提供科学依据。方法对河南省2004-2013年的VAPP病例进行描述性分析。结果河南省2004-2013年共发生VAPP病例19例,VAPP发生率为0.14/100万,首剂服苗VAPP发生率为0.93/100万。VAPP病例男女性别比为8.5∶1,2～6月龄儿童占73.68%。73.68%的病例为首次服苗,服苗至麻痹平均时间间隔为23 d,随访均有残留麻痹。病例便标本病毒分型以Ⅱ型为主。结论 VAPP病例以低月龄、首次服苗儿童为主。应加强接种前预检工作,严格掌握禁忌症。同时适时调整脊灰疫苗免疫策略,减少或避免VAPP的发生。Objective The objective of the study was to analyze the incidence of vaccine-associated paralytic poliomyelitis（VAPP）in Henan Province, and thus to provide a scientific reference for the prevention and control of VAPP. Methods VAPP cases reported in Henan Province between 2004 and 2013 were descriptively analyzed. Results A total of 19 cases of VAPP were reported in Henan Province between 2004 and 2013, with an incidence of 0.14/1, 000, 000 and an incidence after first VAPP vaccine of 0.93/1, 000, 000. The male/female incidence ratio was 8.5： 1, and 73.68% of the cases occurred in children between 2 and 6months old. 73.68% of the patients received the vaccine for the first time, and the average interval between receiving the vaccine and paralysis was 23 days. Residual paralysis was discovered in follow-up visits. Viruses isolated from fecal specimens of the patients was mainly type II virus. Conclusion VAPP patients are mostly children of young age or having received the vaccine for the first time. Pre-vaccination examination should be emphasized and contraindications must be strictly controlled. Meanwhile, polio vaccination strategy should be adjusted timely to reduce or avoid the occurrence of VAPP.

关 键 词：口服脊髓灰质炎减毒活疫苗 疫苗相关病例 流行特征 

分 类 号：R186[医药卫生—流行病学]